There are games that will be impacted by injuries to key players and ones that could impact the best NFL bets for Nov. 26.
The Tampa Bay-Indianapolis, Pittsburgh-Cincinnati, and Buffalo-Philadelphia games are among those that could feature late line movement depending on who is in and who is out.
The Steelers join the Baltimore Ravens, Jacksonville Jaguars, Kansas City Chiefs, New Orleans Saints, and Los Angeles Rams as road teams favored on Sunday. Keep in mind that there is a rare Friday kickoff with Miami playing at the New York Jets.
There are no teams with Week 12 bye weeks.
The 8-1 Philadelphia Eagles have the best record in the NFL and also have the best mark (6-2-2) against the spread after Detroit’s loss. Dallas, Minnesota, Jackson, and Tampa Bay are all covering at least 70% of the time. When looking at the totals, Dallas, Chicago, and Detroit lead the way with seven games going over the total.
When looking at the NFL futures odds, there are two games on Sunday between teams with winning records. One of them involves Philadelphia, one of three teams tied for the best odds of winning the Super Bowl.
Regarding the best picks for the NFL in Week 12, we look at three games most likely impacted by injuries.
Buccaneers vs Colts
Sunday, Nov. 26, 1 p.m. ET (CBS)
There was a time when Tampa Bay had control of the NFC South race after a win over New Orleans.
There is some work to do to get back to that point. Tampa Bay may need to do it without some of its best players on defense.
Cornerbacks Carlton Davis and Jamel Dean are both questionable. They have combined to miss four games. Linebacker Lavonte David is not looking good to play. David has the second-most tackles in franchise history.
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Receiver Chris Godwin is also questionable and that would be a huge blow for the offense if he is limited or unable to play. David, Dean, and White all missed practice on Thursday.
For the Colts, rookie cornerback JuJu Brents is the most noteworthy of the players on the injured report.
The Vegas NFL odds had the opening line at -1½ for the favored Colts and it has since moved to 2½.
Steelers vs Bengals
Sunday, Nov. 26, 1 p.m. (CBS)
Pittsburgh is already without safety Ryan Neal as he landed on Injured Reserve with a rib injury. The Steelers have played the last three games without fellow safety Minkah Fitzpatrick as he fights through a hamstring issue.
Fitzpatrick is tied with linebacker Cole Holcomb for second on the Steelers with 54 tackles. Holcomb landed on injured reserve as a result of a knee injury. Defensive tackle Montravius Adams and linebacker Nick Herbig are questions.
The offense is not immune to the injury bug with leading receiver George Pickens questionable.
Cincinnati will be playing without quarterback Joe Burrow and it is not looking good for receiver Tee Higgins to be available.
Defensive linemen Sam Hubbard (4 sacks) and DJ Reader are also popping up on the injury report as is cornerback Cam Taylor-Britt (team-high four interceptions).
When looking at our NFL odds this week, in a span of nine days the Steelers have gone from 5½ point underdogs to 1½-point favorites.
Bills vs Eagles
Sunday, Nov. 26, 4:25 p.m. ET (CBS)
When the NFL schedule came out, the matchup between the Bills and Eagles could have been viewed as a potential Super Bowl preview.
Philadelphia has lived up to its end of the bargain with an NHL-best 9-1 record. However, Buffalo has stumbled its way to a 6-5 mark.
The biggest concern for Buffalo heading into the late-afternoon kickoff is a secondary with Micah Hyde, Dane Jackson, Taylor Rapp, Cam Lewis, and Taron Johnson all listed as questionable.
That could be a problem going up against a talented Philadelphia offense.
There are questions about the availability of receiver A.J. Brown and tight end Grant Calcaterra. Receiver D’Andre Swift and receiver Quez Watkins are also questionable.
Defensive tackle Milton Williams, defensive end Derek Barnett and cornerback Avonte Maddox are all questionable.
The line has moved from Buffalo being listed as a 2-point underdog to a 3-point underdog according to our sportsbook.
Questions Of The Day
Which team has suffered the most significant setbacks due to player injuries this season?
The Cincinnati Bengals have lost starting quarterback Joe Burrow and it is uncertain when receiver Tee Higgins will be back.
Which team has been the most resilient in overcoming injuries this season?
The Baltimore Ravens have been dealing with the absences of key players all season and currently have the best record in the AFC.