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Home » Bet On NFL Games 2022 » NFL News » Buffalo Bills at New Orleans Saints: Betting Guide

Buffalo Bills at New Orleans Saints: Betting Guide

Paolo Go by Paolo Go
Nov 22, 2021, 1:59pm ET
in NFL News
buffalo bills at new orleans saints nfl 2021

The Buffalo Bills look to shake off another disappointing loss as they head to the Superdome to face the reeling New Orleans Saints, losers of three straight. Buffalo will once again be the favorites according to Las Vegas’ NFL odds. This Thanksgiving duel is shaky ground for online sports betting given the recent struggles of the pair but bettors may find solace in the total instead.

Game: Buffalo Bills (6-4) at New Orleans Saints (5-5)
Location: Caesars Superdome. Date: Thursday, 
Time: 8:20 p.m. ET
Television: NBC

Betting Lines: Buffalo Bills at New Orleans Saints

  • Point Spread: Buffalo -4½ 
  • Moneyline: Buffalo -210, New Orleans +175
  • Total: Over/Under 46½
  • Team Total: Buffalo 26½ -115o/-115u, New Orleans 20½ -120o/-110u

Head-to-Head

Buffalo and New Orleans have faced each other 11 times, with the Saints winning seven of these games. In fact, the Saints have won five straight against the Bills and covered each game as an NFL pick against the spread (ATS). We would have to go back to 1998 for when Buffalo last beat New Orleans: a 45-33 shootout, which is also their highest-scoring meeting.

Buffalo Bills

Next game: vs New England Patriots

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Last Game

The Bills took another one to the mouth as the Indianapolis Colts went to Buffalo and beat the brakes off the home team 41-15. It was ugly from the start as the Bills committed several turnovers and were not remotely close to winning or covering their seven-point spread. The loss dropped Buffalo’s record against non-losing teams to 1-3.

At what point though does it become who they are? This isn’t the first time we’ve heard this this season. https://t.co/kSigNherAz

— Bradley Gelber (@BradleyGelber) November 21, 2021

Injury Report

The Bills continue to be without star linebacker Tremaine Edmunds (hamstring). Guard Jon Feliciano (calf) is also ailing.

New Orleans Saints

Next game: vs Dallas Cowboys

Last Game

With their third straight loss on Sunday, the Saints dropped back to .500. Philadelphia beat New Orleans 40-29 but this score is deceptive as the Eagles beat up New Orleans from the gate, going up 27-7 in the first half. A furious rally in the fourth was all for naught as the Saints still fell awfully short of their spread of +3.

Injury Report

Injuries have been a shadow for the Saints, who are beginning to feel their effects. New Orleans was without lead running back Alvin Kamara (knee) against the Eagles along with receiver Ty Montgomery (finger), and tackles Terron Armstead (knee) and Ryan Ramczyk (knee). On defense, Malcolm Roach (knee) was placed on injured reserve on Saturday.

Betting on the Game

At this point, Bills games feel like we should be betting online on the underdog. We found the value on the Colts at +270 last week so it’s not crazy to think that the reeling Saints at +175 could pull another upset here. The market is slowly adjusting to Buffalo, as New Orleans should be a bigger underdog here considering their situation.

The Saints are down to Trevor Siemian at quarterback, who entered the season with a 79.8 passer rating. He has not won a game with the Saints and has turned the ball over four times. New Orleans has also only barely covered the spread once in his three appearances as a starter.

Buffalo returns to the road where it is marginally better with a 3-2 ATS record. The Bills blew out Kansas City and the New York Jets but also suffered upset losses to Tennessee and Jacksonville, the latter as a 14½-point favorite.

Now, the Bills face the Saints, who are 4-1 ATS as an underdog. The defense will need to return to form and Josh Allen will need to start playing like the MVP front-runner that he’s supposed to be. In their four losses, Allen has thrown for six touchdowns while turning the ball over seven times.

But against the Saints, who have had a tough time applying pressure on opposing quarterbacks, Allen should be able to bounce back. Buffalo is 3-0 when Allen does not turn the ball over. The Bills can flip the script here and be the one forcing the Saints to cough up the ball.

Buffalo should be able to get this one done. The team has not lost consecutive games since Week 6 of last season. But against the recent trend of their games being high-scoring – six of New Orleans’ last seven games and four of Buffalo’s last six have all gone over – this one may be dictated by some ugly quarters and fewer points.

Final Score: Buffalo 23, New Orleans 20

If your plans include staying at home all day enjoying the best league in the world, don’t forget that we we also have NFL Odds for the Bears vs Lions & Raiders vs Cowboys games that you can include in your parlays or NFL Point Spreads wagers.

Tags: Buffalo BillsNew Orleans SaintsNFL
Paolo Go

Paolo Go

As a long-time Toronto Raptors and Buffalo Bills fan, Go Paolo knows that every dog gets its day. Paolo fancies himself as an underdog in the sports betting world as he does not come from a traditional sports background. He did not become a hardcore sports fan until his freshman days in college studying Mass Media and Communications. While he played basketball and trained in martial arts, Paolo sees himself more as a nerd who cut his teeth in sports analysis by dropping truth bombs and stone-cold facts against crazed fans from online message boards. It was here he caught the attention of several sports journalists and website owners who gave him his start as a sportswriter. He has since published with the likes of Sportsnet and FanSided and has been writing about sports betting for over five years. Paolo is thrilled to continue covering sports and cannot wait to unearth more underdogs and unconventional winners.

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