The Los Angeles Rams head up the coast to face the San Francisco 49ers in their first NFC West division rivalry clash of the season. Devastating injury has plagued the Niners and the sportsbook lines them as a home dog. Our injury news breakdown details who’s among the walking wounded and how that should impact your bets.
| Game: Los Angeles Rams (4-1) vs San Francisco 49ers (2-3) Location: Levi’s Stadium Time: 8:20 p.m. ET Television: NBC |
A case study in young coaches, Sean McVay and Kyle Shanahan began their head-coaching tenures at the same time three years ago. Both have struggled with the Super Bowl hangover, currently more of a Niners’ problem. Their head-to-head record straight up and against the spread both is a wash, at 3-3.
Rams vs 49ers Betting Odds Week 6 –NFL Betting Lines
| Team | Point Spread | Moneyline | Over/Under | Team Total |
| Rams | -3 | -150 | 51½ | 27 |
| 49ers | +3 | +130 | 51½ | 24 |
Los Angeles Rams
In comparison to many other teams, only losing a couple of players in a week to season-ending injury can be scored as a win. So is the case for these Los Angeles Rams, their biggest loss being S Jordan Fuller, on IR. Fuller hadn’t played since Week 3.
Also lost for at least this game is OLB Ogbonnia Okoronkwo, slated for surgery on his elbow to repair damage caused in the second half of last Sunday’s game.
Otherwise, the Rams have only one question mark leading into Sunday night’s affair, the likelihood of starting ILB Micah Kiser. Limited in practice with a groin strain and listed as questionable, Kiser’s name is worth checking to see if he’s among the 45 getting dressed.
San Francisco 49ers
Meanwhile, up in the Bay Area the atmosphere is a bit more circusy.
The Niners were in no rush to provide public clarity about the state of quarterback Jimmy Garoppolo. So for a couple of days, pundits entertained a vigorous C.J. Beathard versus Nick Mullins debate which, fortunately, no one had to win as Jimmy’s ankle healed over the course of the week.
Backup running back Jeff Wilson came down with a midweek calf problem that kept him out of practice for the last two days, never a good sign for availability.
The bigger problems for San Francisco come on the other side of the ball. On a defense already down about seven starters, the Niners can ill afford to start losing replacements. Yet, CB Dontae Johnson (groin) will miss his second consecutive week and now OLB Kwon Alexander has been designated out with a high-ankle sprain.
Two much-needed names to watch for on the inactives list before kickoff are S Marcell Harris and CB Emmanuel Moseley. Moseley needed to pass his final concussion protocol test, which seemed promising. On the other hand, Harris appeared on the injury report with an ankle and didn’t practice at all the final two days. (Again, never a good sign.)
Rams vs 49ers Betting Odds Week 6 -Leans
Earlier in the week, support came for the 49ers when they were getting +3½ and continued through +3. (They’re now a pricey plus three.) We liked it too (and took it on the writers’ picks) but assessing the injury profile now, it’s not as appealing. Considering Rams’ CB Jalen Ramsey is expected to erase either wide receiver Deebo Samuel or Brandon Aiyuk from the stat sheet, it’s more than likely Jimmy G. will get ample chance to test his ankle scrambling out of the pocket as Aaron Donald chases him down.
If the spread dropped to -2½ and San Francisco came up empty on their three actually-questionable players (not Jimmy), we’d consider laying that less than a field goal with the Rams.
Much more appealing is the total, which we leaned under at 51 and really like under 51½. While the game could certainly end higher than the 27-24 projection, Sean McVay surely has a bunch of alternative game scripts where the Rams win a 10-3 or 13-10 slobber knocker. If Harris and Moseley are active, we’d love under 51½ and then hope it was still on the board.
Here is a look at the latest Super Bowl Odds.
