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San Francisco 49ers at Philadelphia Eagles: Betting Guide

Unbeaten records are on the line as West meets East in the NFC.

Jimmy Garoppolo secured his position as the San Francisco 49ers quarterback, but he could be outshined by Jalen Hurts, who had the better opening week for the Philadelphia Eagles.

Miles Sanders of the Philadelphia Eagles carries the ball against the Atlanta Falcons during the second quarte
Todd Kirkland/Getty Images/AFP

It’s conference football and it should be a tight contest.

  • Game: San Francisco 49ers (1-0) at Philadelphia Eagles (1-0)
  • Location: Lincoln Financial Field. Date: Sunday
  • Time: 1 p.m. ET
  • Television: FOX

Betting Lines

Team Point Spread Moneyline Over/Under
San Francisco 49ers -3½ -180 o50
Philadelphia Eagles +3½ +160 u50


The 49ers and Eagles have met on 34 occasions, with the 49ers holding a 19-14-1 record.

Despite an historical edge for the 49ers, it’s the Eagles entering the Week 2 game with momentum. They have won the last two meetings, but only one was played in the last three years.

Philadelphia won 25-20 in San Francisco last year, but with no fans at the stadium, it didn’t play like an away game. Neither Hurts or Garoppolo were involved in the game, so the quarterback situation is distinctly different.

San Francisco 49ers

Next game: vs Green Bay Packers

Last Game

Las Vegas NFL odds had the 49ers as -9½ favorites to beat Detroit last Sunday and the game left bettors with a sour taste in their mouths.

The 49ers were on cruise control until the final quarter when they allowed the Lions to score 16 points. Bettors who took the 49ers -9½ were sitting pretty with a 28-point lead, but instead had to endure a bad beat.

San Francisco looked good for the most part, despite taking its foot off the gas. Garoppolo went 17 of 25 for 314 yards and one touchdown in what was a solid effort.

Running back Elijah Mitchell was the standout rusher for the 49ers, going for 104 yards on 19 carries and one touchdown after replacing an injured Raheem Mostert. However, it pales in comparison to wide receiver’s Deebo Samuel’s 189-yard effort.

Samuel scored one touchdown on nine receptions, but he was busy and connected with Garoppolo nicely.

Injury Report

Mostert remains on the sidelines. He is joined by cornerbacks Jason Verrett and Davontae Harris.

Dre Greenlaw, who recorded an interception in the 41-38 win over the Lions, could potentially miss the game due to a groin injury.

Philadelphia Eagles

Next game: vs Dallas Cowboys

Last Game

It was a tough game for those who bet on NFL last week when the Eagles faced the Atlanta Falcons.

The Falcons were expected to beat Hurts and the Eagles, but Philadelphia turned up and produced a comprehensive upset as four-point underdogs.

“We wanted to come out in Week 1 and start off the right way,” Hurts told ESPN. “It feels good.”

Despite starting the game as a largely unwanted betting proposition, the Eagles showed that they could be a force with a 32-6 win over the hapless Falcons.

Hurts had 264 yards for three touchdowns. He was economical, going 27 of 35 in what was one of his finest games as a quarterback. He connected with DeVonta Smith for the first touchdown of the game before linking up with Dallas Goedert and Jalen Reagor.

The under was 49 points so it hit comfortably. It was helped by Atlanta not scoring in the second half.

Injury Report

Marcus Epps and Andre Dillard are in doubt to play against the 49ers. Landon Dickerson and Davion Taylor are also in doubt, but the biggest potential omission is tight end Zach Ertz, who is nursing a hamstring injury.

Betting on the Game

Point Spread

We are not surprised to see the 49ers as -3½-point favorites, mostly because they’re a public betting team, but we’re picking the Philadelphia Eagles to cover the spread.

Playing at Lincoln Financial Field is always a positive and they’re coming off an impressive opening-week performance.

NFL picks against the spread are all about extracting as much value from the bookmaker as possible and we think getting +3½ points is a generous line.

San Francisco isn’t always the best travelling team and we still have questions about Garoppolo. We have less doubts about Hurts.

The 49ers are also 2-7 against the spread in their last nine meetings against Philadelphia. The Eagles are also 5-0 in their last five games as a home underdog, so it further strengthens our pick.

Given the confidence from beating Atlanta on the road, we think the Eagles will firm in points spread betting markets. We don’t predict the line to move, but the -110 could easily become -130 by kickoff.

Philadelphia knows it has Dallas the following week, so starting 2-0 would be the ideal situation heading into a tough divisional game. Bettors could make the case that the Eagles are in a look-ahead spot, but we think securing wins over the likes of the 49ers is important for their momentum.

Value is with the Eagles, who rarely find themselves as home underdogs against a team that went 6-10 in the previous season.


As much as we like the point-spread option, we love the moneyline available with the online sportsbook.

Philadelphia is paying +160 to win outright and we can’t turn down that value. We framed the Eagles as three-point favorites, so we’re happy with the odds available.

There is a possibility the moneyline odds for the Eagles could firm without it affecting the spread. The Eagles could firm into +140, so we recommend taking the +160 available for the home underdog.

It’s an excellent situation for the Eagles to start the season a perfect 2-0.


The offenses look capable of piling on the points, but the Eagles are used to playing in low-scoring games.

Bookmakers have the line at 50, which is higher than we expected. Philadelphia’s games have gone under that total in nine of its last 11 games.

Despite the 49ers scoring 41 points against the Lions, there was little defensive pressure put on them. Philadelphia will make it much harder to score, which should result in more field goals than touchdowns.

Final Score: Philadelphia Eagles 26, San Francisco 49ers 20

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