49ers vs Cardinals Same Game Parlay for January 05: Bet Defenses to Reign

The games between two teams that failed to make the playoffs – like the Arizona Cardinals hosting the San Francisco 49ers – are even more difficult to uncover.

The 49ers started the season as one of the favorites in the odds to win the Super Bowl while the Cardinals held down first place in the NFC West in midseason before losing five of the last six contests.

San Francisco won’t have No. 1 quarterback Brock Purdy in the lineup due to injury and Arizona will want to make the home fans in Glendale go into next season with more hope after an eighth victory.

It’s a tough one, but we have some ideas for your same-game NFL parlay ahead.

Top 3 Parlay Picks for 49ers vs Cardinals

1. Bet the Under to Start Parlay

The odds for Arizona to hit the moneyline are not very good, and giving up four or five points to the 49ers does not seem appetizing, either. A reasonably low-scoring game seems a better bet.

The Cardinals held NFC West champ Los Angeles to 13 points last week and San Francisco should have some pride. Per 49ers vs Cardinals stats, San Francisco is still sixth in the league in yards against per contest.

Purdy won’t play for San Francisco and Arizona’s top two running backs James Conner and Trey Benson went on IR. Unless the secondary and pass rushes are below par, the scoring could be held down.

Take under 43 points (-110) to start your same-game parlay.

PARLAY PICK: Under 43

2. RB Isaac Guerendo Anytime Touchdown

San Francisco’s Isaac Guerendo started the season third or fourth on the depth chart at running back. With Christian McCaffrey and Jordan Mason on IR, he has gotten a chance and is taking advantage.

Guerendo has run for 415 yards and four touchdowns, averaging 5.1 per carry. With journeyman Joshua Dobbs replacing Purdy, Guerendo will probably get an opportunity to make an impact in NFL player prop betting.

Anybody can run it in Shanahan’s run scheme. Unrealpic.twitter.com/MxxFwQiAat

— Chase Daniel (@ChaseDaniel) October 11, 2024

Tight end George Kittle, along with receivers Jauan Jennings and Deebo Samuel, will get looks from Dobbs if they suit up. However, Kittle and Samuel are questionable. Check late NFL news to see who will play in the final game.

Bet Guerendo to score a touchdown in NFL picks and add it to your parlay.

PARLAY PICK: Isaac Guerendo Anytime Touchdown (+140)

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3. Bet Arizona Scores on First Drive

The Cardinals struggled to score last week in the 13-9 loss and will have their early plan mapped out and ready for Sunday.

The 49ers gave up 40 points to one of the best offenses in the league (Detroit) last week and could be a little worn down. They may be vulnerable until settling into the game, so use Arizona to get some points right away for your NFL predictions.

Kyler Murray signaling that he knew he was gone at the 44-yard line with defenders right on his tail is peak Kyler Murray

Incredible #Sooners pic.twitter.com/aRG0fBWped

— Josh Callaway (@JoshMCallaway) October 6, 2024

Arizona quarterback Kyler Murray, who has rushed for 550 yards (7.3 per carry), will want to finish his up-and-down season on a high note. Murray (17 TD passes, 11 interceptions) helped rally the Cardinals from 13 points down to win at San Francisco 24-23 on Oct. 6. Bet Arizona gets points on its first drive (+140).

PARLAY PICK: Arizona Scores on First Drive (+140).

Need More Knowledge? Take a Look at Other NFL Betting Articles

• Lions vs 49ers Picks, Prediction and Odds for Monday Night Football Week 17 Dec 30
• Cardinals vs Rams NFL Parlay Picks: Bet on Rams ML and ATS on Dec 28

Questions Of The Day

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets