49ers vs Dolphins Parlay Picks: Bet This TD Prop on December 22
- The 49ers vs Dolphins betting line features a virtual pick’em game.
- 49ers QB Brock Purdy has one touchdown pass and four interceptions against AFC foes this season.
- Get the best NFL odds at BetUS.com Sportsbook!
Most of your online betting for the game between the visiting San Francisco 49ers and Miami Dolphins on Sunday will depend on who is in uniform, so hold on until close to gametime.

Miami quarterback Tua Tagovailoa (hip) is hurt while two of his top receivers, Tyreek Hill and Jaylen Waddle, have missed practice time. Meanwhile, the 49ers could be down to their fourth-string running back. Monitor NFL news for updates on their status.
We expect many of the injured players to be in the lineup and that could lead to some points, but that scoring may come later in the game.
The game does not have a favorite, but it has plenty of value to use in NFL picks and parlays. We have some ideas ahead!
Top 49ers vs Dolphins Parlay Picks 12/22
1. Field Goal Gets Things Started
These teams are not realistically in the playoff race, so with this type of game, the defenses may be tight early before the offenses take over.
If you want to get some serious value in your parlay, bet on a field goal to start the scoring on Sunday. You get +320 NFL prop odds for a 49ers field goal making it 3-0 and +310 if the Dolphins kick a field goal to score first.
San Francisco allows the third least yards per game in the NFL and Miami is sixth, so you can expect either team to be stingy for a while. You might even want to use over 7 minutes for the first points (+106) in your parlay.
Dolphins kicker Jason Sanders has not missed a field goal in his last eight games and Jake Moody of the 49ers kicked a 53-yarder last week.
Jason Sanders hit his 7th straight 50+ yard field goal Sunday, the longest active streak in the NFL this season. #GoFins pic.twitter.com/R4yd51lRyc
— Dolphins Muse (@Dolphins_Muse) December 17, 2024
Use the Miami Dolphins to make it 3-0 (+310) and/or over 7 minutes for the first points (+106).
Bet on Dolphins FG First Scoring Play of Game (+310)
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2. Use Tight End Touchdowns In Best Parlay
If both quarterbacks are healthy and well protected, you can expect a few touchdown passes.
Tagovailoa had 11 scoring strikes and no interceptions in four games before last week (one, three) while San Francisco’s Brock Purdy had 31 TD passes in 2023 and owns 15 this season. Per 49ers vs Dolphins betting tips, Purdy has not done well against the AFC this season (one TD, four interceptions), though.
Both have solid receivers to get the ball to, but when they get near the end zone it might be the tight ends who see the ball. Miami’s Jonnu Smith (70 catches, six TDs) and George Kittle of the 49ers (60 catches, 861 yards, eight TDs) are the best NFL player props for your parlay.
Jonnu Smith told McDaniel to get him the ball in Overtime and this is how he responded. Jonnu had me HYPE watching his response after each play ‼️📈 #ProBowlVote
– 3 Rec
– 44 YDS
– Game Winning TD pic.twitter.com/irDKnyiNFl— Bobby Shouse (@B_Shousejr) December 10, 2024
Kittle has +170 odds to score at least one touchdown while Smith, who has scored five times in the last five games, has +210 odds.
Use Smith to score at least one touchdown (+210) in your NFL predictions.
Bet on Jonnu Smith Anytime Touchdown (+210)
More 49ers vs Dolphins Week 16 Bets and Picks
49ers vs Dolphins Predictions: Bet Miami for Straight-Up Win December 22
Question of the Day
Where do Smith and Kittle rank among tight ends in receiving yards?
Kittle is third with 861 yards and Smith is fourth with 740.
Who leads Miami in touchdowns?
Dolphins running back De’Von Achane (10) has four rushing scores and six receiving TDs.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.