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49ers vs Dolphins Predictions: Bet Miami for Straight-Up Win December 22

  • Get the latest 49ers vs Dolphins odds at BetUS.com Sportsbook!
  • The San Francisco 49ers visit the Miami Dolphins on Sunday for a pick’em game between two teams barely alive in the playoff hunt.
  • Miami quarterback Tua Tagovailoa leads the league with a 73.7 completion percentage.
  • Find my top 49ers vs Dolphins predictions ahead.

 

The Miami Dolphins are a tentative NFL moneyline pick as they prepare to host the San Francisco 49ers on Sunday in a game between two of the most disappointing teams in the league.

49ers vs Dolphins Predictions: Bet Miami for Straight-Up Win December 22
Tua Tagovailoa #1 of the Miami Dolphins | Carmen Mandato/Getty Images/AFP

Both teams need to win their final three games and get a lot of help to make the playoffs at 9-8, so this matchup becomes one more about pride. The 49ers have lost four of five and the Dolphins are 4-2 in the last six, but they dropped a 20-12 decision at Houston on Sunday.

San Francisco has had injury issues throughout the year and Miami was without quarterback Tua Tagovailoa for four games early in the season. Health is the biggest factor in this game as key players have missed practice time. Check late NFL news for who is in and out.

Your pick on this game comes down to who you feel is ready to play at the highest level emotionally. It’s not an easy one.

 

49ers vs Dolphins Game Information

  • Game: San Francisco 49ers (6-8) vs Miami Dolphins (6-8)
  • Location: Hard Rock Stadium, Miam, Fla.
  • Day/Time: Sunday, Dec. 22, 4:25 p.m. ET
  • 49ers vs Dolphins Live Stream: NFL Game Pass

 

49ers vs Dolphins Odds and Spreads

49ers
Dolphins
pk -110
Point Spread
pk -110
O 44½ -110
Total
U 44½ -110

Place your Bets on 49ers vs Dolphins at BetUS Sportsbook!

 

  • Miam has only hit the team total over in seven of its last 20 contests.
  • The 49ers have covered the first quarter spread in seven of the last 10 road games.
  • The Dolphins have only hit the second half moneyline in four of their past 15 outings.
  • San Francisco has hit the second half game total over in 12 of its last 17 games.
  • Miami has won four of the last six meetings, but lost 33-17 at San Francisco in 2022.

 

Top 49ers vs Dolphins Betting Tips

1. Bet Miami Offense to Unlock Win

It depends on who plays for Miami, especially Tagovailoa.

The Alabama product leads the league in completion percentage (73.7), but struggled last week with one TD pass and three interceptions. Tagovailoa is also hampered by a hip injury and all bets are off if he does not suit up.

Per 49ers vs Dolphins stats, Tagovailoa had 11 scoring strikes without an interception in four games before the trip to Houston. His two top receivers, Tyreek Hill (805 yards) and Jaylen Waddle (700), have also missed time in practice this week.

If Tagovailoa is ready to go, he does have tight end Jonnu Smith (70 catches, 740 yards) and running back De’Von Achane (641 yards, 10 total touchdowns) to help win your bet at the BetUS sportsbook.

If Tagovailoa plays, bet the Dolphins moneyline.

Bet this Pick: Dolphins (-110)

 

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2. Why Bet Against the 49ers Again?

San Francisco was one of the favorites to win the Super Bowl before the season, but little has gone right for the 49ers this season.

Star running back Christian McCaffrey has missed most of the season with injuries and Jordan Mason, who took over as the top rusher, is also out with an ankle injury. Even a third successful back, Isaac Guerendo (5.2 yards per carry, four TDs), is questionable for Sunday.

Quarterback Brock Purdy has not been productive (15 TD passes, nine interceptions) and receiver Deebo Sanuel has made it to the end zone just twice. Tight end George Kittle (60 catches, 861 yards) is still a threat.

The 49ers are still third in the league in yards against per game on defense, but they are giving up 22.9 points per contest (17th in the NFL). That does not make them a safe online bet over the final few games.

Bet more on San Francisco in 2025 NFL futures.

 

3. No Reason For Tight Defense In Miami

Realistically, these teams have a much better chance to make the playoffs next season than next month. So why not have some fun?

Unless a lot of the banged-up players sit this one out, we think there will be enough scoring to beat the relatively-low number at 44 ½ points. Purdy and Tagovailoa are the keys to your NFL bets today strategy on this contest.

Four Dolphins have accumulated 500 yards through the air this season and combined for 19 touchdowns. Kittle (eight) and Jauan Jennings have totaled 14 receiving touchdowns for San Francisco and are top options in NFL player prop bets.

Bet over 44½ points and hope the offenses don’t sputter like they did last week (18 points combined).

Bet this Pick: Over 44½

 

More 49ers vs Dolphins Week 16 Bets and Picks

 

49ers vs Dolphins Odds and Best NFL Prop Picks: Bet George Kittle, Jonnu Smith to Score a TD December 22

49ers vs Dolphins Parlay Picks: Bet This TD Prop on December 22

 

Questions of the Day

When was the last time San Francisco finished under .500?


In 2020. The 49ers finished 6-10 and have reached the NFC Championship Game each of the last three seasons.

When was the last time Miami won a playoff game?


In 2000. The Dolphins lost in the AFC wild-card playoffs the last two seasons.

 

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.

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