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Best NFL Prop Bets for Sept. 17: Ride 49ers Offense Against Rams

The Los Angeles Rams will be looking to double up their winning ways when they try to go for their second straight divisional win, this time against the San Francisco 49ers. The issue at hand is that they’ll go against one of the best teams not only in the NFC but the league in general, perennial NFL odds favorite, the San Francisco 49ers.

With the Niners as clear betting favorites to take this divisional bout and the NFC West title down the line, what are some of the best NFL prop bets for Sunday’s game? Let’s run down a couple of options.

Best NFL Prop Bets for Sept. 17: Ride 49ers Offense Against Rams
Best NFL Prop Bets for Sept. 17: Ride 49ers Offense Against Rams

Can LA Stop San Francisco?

Last season, even with San Francisco’s QB debacle, the Niners were able to hold down the then-defending Super Bowl champion Rams. With a 24-9 win and another 31-14 victory later down the season, the Niners showed LA they owned the NFC West, and from the looks of it, they’ll want to show off their dominance again on Sunday.

When comparing both teams’ performance in Week 1, San Francisco put on a show in Pittsburgh, keeping the Steelers to scraps. Meanwhile, LA scratched their way to beating an errant Seattle Seahawks, with Geno Smith apparently not aware that the new season had already started.

For this Week 2 encounter, it will be up to Brock Purdy, Deebo Samuel, Christian McCaffrey, Brandon Aiyuk, and the rest of San Francisco’s offense to put Aaron Donald and Leonard Floyd to the test and topple LA’s defense.

LA’s best chance at a win will come from its defense becoming a wall to stop San Francisco’s offense. The mission is simple, and the rewards are plenty. It will be up to Sean McVay and DC Raheem Morris to come up with a bullet-proof strategy and pray for the best.

Do I see it happening? No, but wilder things have happened.

Rams vs 49ers Game Information

  • Game: Rams (1-0) vs 49ers (0-1)
  • Location: SoFi Stadium, Los Angeles, California
  • Day/Time: Sunday, Sept. 17, 4:05 p.m. ET
  • Rams vs 49ers Live Stream: NFL Game Pass

NFL Pick: Niners to Easily Score Over 2.5 TDs

The Niners make talking about football so easy that it should be illegal. Just like last season and in Week 1, NFL game predictions experts saw that betting on San Francisco to score various times in a game was one of the best wagers to take.

In Week 2, against a team like the Rams – who surprised NFL online betting fans left and right by beating the Seahawks last week – the chances to have another high-scoring affair are ample.

The Niners have a better offensive line than Seattle, meaning that Purdy will have better protection to move the ball around. The Niners have a better receiver core and running game. In addition, they are led by one of the best offensive-minded coaches in the game. All this adds up to betting on the Niners having over 2.5 TDs being as easy as pie.

NFL Pick: San Francisco Total TDs Over 2.5 (-205)

McCaffrey Scoring Twice and SF to Win? Winning Duo Right Here

The science is simple here. If the Niners were able to dominate in Week 1 against Pittsburgh’s defense, led by T.J. Watt, what’s there to stop them from dominating LA’s defense led by Donald and Floyd? Once San Francisco’s O-line creates gaps within LA’s frontal defense for McCaffrey to run loose, I could easily see him score at least twice in the game, especially in the red zone.

Our NFL betting lines show the Niners as favorites to win this game, so why not spice things up a bit with a duo of prop bets?

Take San Francisco’s elite RB to score twice and the Niners to win on the road as they solidify their stats as the best team in the NFC West. Our sportsbook has that double pick at +239. If it’s easy money you’re looking for, easy money you shall get.

NFL Pick: Christian McCaffrey to have 2+ touchdowns and SF to win (+296)

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