Colts vs Patriots Picks, Prediction and NFL Game Prop for December 1st
- Check the latest Colts vs Patriots betting lines at BetUS
- Indianapolis looks to win back-to-back games against New England since the 2008 and 2009 seasons.
- Each of the last three games between the Colts and the Patriots landed under the total.
- Find my top Colts vs Patriots NFL Week 13 picks ahead.
The Indianapolis Colts and the New England Patriots are rebuilding with young quarterbacks taken in the top five picks in recent NFL Drafts. This will be the first matchup between Anthony Richardson of the Colts and New England rookie Drake Maye. The NFL betting spread has the Colts as the road favorite for the second meeting in a row.

Heading back to the East Coast this weekend. pic.twitter.com/BSqxgt6oqF
— Indianapolis Colts (@Colts) November 27, 2024
The Patriots defeated the Colts eight times in a row from 2010 to 2018. However, Indianapolis has won two of the last three meetings. In last season’s matchup, Jonathan Taylor had the only touchdown late in the first quarter in a 10-6 win for the Colts. It was the third game in a row between the Colts and the Patriots to land under the total.
The BetUS sportsbook has Indianapolis listed as a 3-point favorite with -145 odds to win outright. The Patriots are priced at +125 to come up with their second home victory of the season.
Colts vs Patriots Game Information
- Game: Colts (5-7) vs Patriots (3-9)
- Date/Time: Sunday, Dec. 1, 1 p.m. ET
- Location: Gillette Stadium, Foxborough, MA
- Colts vs Patriots Live Stream: NFL Game Pass
New England has lost seven of its last eight games as the home underdog, four of which came this season. Five of the last six times that the Patriots have been the underdog at Gillette Stadium, the game landed over the total.
The Colts fell to Green Bay 16-10 in its only other game as the road favorite. Indianapolis won its final three games during the 2023 season when favored on the road. Per Colts vs Patriots betting tips, seven of the last eight matchups with Indy favored on the road landed under the total.
Colts vs Patriots Odds and Spreads


Place your Bets on Colts vs Patriots at BetUS Sportsbook!
Top 3 Colts vs Patriots NFL Week 13 Picks
1. Bet on No Score in First 7 Minutes (+100)
Since returning from London following a 16-point loss to Jacksonville, the Patriots had four one-possession games in a span of five weeks. The lone exception was a 19-3 win over the Chicago Bears. The momentum stopped when Miami jumped out to a 31-0 lead on the way to a 19-point win.
The last two losses for the Colts have come to the Detroit Lions and the Buffalo Bills, two of the top Super Bowl contenders. In between those games, the Colts edge the New York Jets. The Colts haven’t scored a touchdown in the first quarter in the last four games. New England has one TD in the first quarter just once during that same stretch.
Going by the NFL trends, the +100 odds for neither team to score in the first seven minutes are pretty tempting.
Bet on first score in the Colts vs Patriots game not coming in the first seven minutes (+100)
2. Back Patriots ML (+125)
This is a hard game to get a feel for as the Colts are just 2-4 on the road while the Patriots have won only one of its first five home games.
With the Patriots offering some value at +125 as the home underdog, that is enough to go with New England to find a way to win this game. It helps that Maye, in his rookie season, is passing the eye test more frequently than Richardson, the Colts’ second-year quarterback.
The Patriots winning outright is the best NFL expert pick today.
Bet Patriots to Win Outright (+125)
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3. Bet This Game to Land Under 42.5
We would feel a little better if the total moved a couple of points from 42.5 but this is hardly a matchup of unstoppable offenses. Neither head coach is letting their talented young quarterback cut it loose, so with that in mind, go with the Colts-Patriots matchup to finish under.
Two of the previous three games between the Colts and Patriots had 29 and 16 points scored. That is enough to go with the game and land under when making NFL picks.
Receiver DeMario Douglas, defensive backs Kyle Dugger and Jabrill Peppers and edge rusher Keion White are among the players for the Patriots who have been practicing on a limited basis this week.
Patriots Wednesday injury report: https://t.co/pBXOqFVnMH pic.twitter.com/27cwX7NpKu
— New England Patriots (@Patriots) November 27, 2024
Receivers Josh Downs, Ashton Dulin and Alec Pierce join offensive linemen Tanor Bortolini and Braden Smith have been missing practice time for the Colts.
Check NFL news for an updated injury list before placing a bet on the game.
Bet on the Colts vs Patriots Game to go Under 42.5
Colts vs Patriots Score Prediction
Patriots 23, Colts 17
Bet the Patriots to Take this Game Against the Colts at BetUS!
Questions Of The Day
How has Indianapolis fared as the betting favorite against New England?
The Colts have won their last two games and covered in each of them when favored against the Patriots.
Which team has a better record against the NFL spread this season, the Colts or the Patriots?
Indianapolis is 8-4 and New England is 4-7-1 against the spread this season.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets