Jaguars vs Colts Picks, Prediction and Odds for NFL Week 18, January 05
- The Jaguars vs Colts betting line has the Colts favored at -5.
- The Jaguars and Colts are playing for pride in the final week of the regular season.
- Find my top Jaguars vs Colts NFL picks ahead.
We have NFL Week 18 picks for the Jacksonville Jaguars vs Indianapolis Colts, where the latest NFL odds have the Colts at -5.

The playoffs are off the table for the Jags and Colts, so this game is all about capping which AFC South team wants the win more for pride.
Jaguars vs Colts Game Information
- Game: Jaguars (4-12) at Colts (7-9)
- Date/Time: Sunday, Jan. 5, 1 p.m. ET
- Location: Lucas Oil Stadium, Indianapolis, IN
- Jaguars vs Colts Live Stream: CBS
Get Jaguars vs Colts betting tips here.
Jaguars vs Colts Odds and Spreads


Place your Bets on Jaguars vs Colts at BetUS Sportsbook!
Jaguars vs Colts Best Bets and TD Prop Picks
1. Indianapolis Colts ATS -5
The Colts will likely be without quarterback Anthony Richardson, but Joe Flacco is a good fill-in and they still have running back Jonathan Taylor.
We have been impressed with Taylor over the last few weeks, and he features in our NFL player props. He could make all the difference for the Colts, and we expect him to run straight through the Jaguars defense.
Jonathan Taylor vs Titans a week after his costly fumbled touchdown:
29 carries for 218 rushing yards (7.5 ypc) and 3 rushing TDs pic.twitter.com/xMIneAwF74
— Noah Compton (@nerlens_) December 22, 2024
Disappointed to lose 45-33 to the Giants with everything on the line last week, the only way forward for the Colts is to win their final game. Losing to the Jaguars would be a terrible way to bring in 2025, so the team with more heart should win.
That’s the Colts, and we’re backing them to cover the -5 NFL spread.
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2. Jaguars vs Colts Under 45
Points will be tough to come by for the Jaguars and Colts, and this is one of our more confident NFL bets today in the Week 18 game.
The Colts have more points in them, but the Jaguars defense isn’t all that bad, having given up only 13 points against the Titans last week and 19 points when losing 19-14 to the Las Vegas Raiders.
Bettors don’t have much room to work with at 45 points, but our final score prediction is 23-16, which gets the job done for under 45 backers. It’s a fair NFL betting line, so include it in picks on Sunday.
Bet this Pick: Jaguars vs Colts Under 45
3. Largest Lead: Under 16½ Points (-148)
Our best NFL prop bet is the largest lead under 16½ points, and it’s well worth including in NFL picks and parlays.
Bettors get -148 to include in parlays, and we can’t turn down those odds. We can’t see the Jaguars or Colts getting out to a 17-point lead, so we’re surprised by the big line offered by our BetUS sportsbook.
The biggest lead we envision is 13 points, and that’s at a stretch. They are likely to trade field goals for the most part, so this is our most confident prop bet for the Jaguars vs Colts in Week 18.
Bet This Pick: Largest Lead Under 16½ (-148)
4. Jonathan Taylor 2+ Touchdowns
One of our best NFL player TD prop picks is Taylor to score twice for the Colts.
The running back has been in devastating form for the Colts recently, including three touchdowns against the Titans before adding two more TDs to his record last week against the Giants.
A big end to the year was needed for Taylor, who had come under fire for underperforming, but he has shown why he’s still one of the best NFL running backs. Per Jaguars vs Colts stats, Taylor got 32 carries last week, and if he gets a similar workload against the Jaguars, he could score the Colts only two touchdowns of the game.
Bet This Pick: Jonathan Taylor to Score 2+ Touchdowns (+300)
More Jaguars vs Colts Week 18 Bets and Picks
- Jaguars vs Colts Same Game Parlay for January 5: Fade Total TDs
- NFL Player Props Picks Jaguars vs Colts on January 05: Taylor Best TD Bet
Questions of the Day
What are the moneyline odds in the Jaguars vs Colts game?
The Indianapolis Colts are -225 moneyline favorites to beat the Jacksonville Jaguars (+190) on Sunday.
Who won the most recent meeting between Jacksonville and Indianapolis?
The Jaguars won the most recent meeting 37-34 in 2024, but the Colts lead 27-20 in the all-time matchup.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.