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NFL ATS Best Bets Week 2

Double-Digit Spreads to Play at Lambeau, LA and by the Bay

We’re back with our selection of NFL ATS bets for Week 2 in this weekly column. This week brings some daunting double-digit point spreads, quite a few tight lines, several pivotal divisional contests and a handful of teams looking to bounce back after horrendous debuts.

Who will win and/or cover for NFL picks against the spread?

Week 2 ATS Picks
Jared C. Tilton/Getty Images/AFP

Read on for our game preview and quick-fire NFL predictions below, which include the latest stats, injury reports and NFL odds, capped off with choice NFL picks for your consideration.

NFL Week 2 ATS Predictions & Picks

  •  Jets (+6½) vs Browns
    Sunday, 1 p.m. ET, CBS

Do the Cleveland Browns merit praise for eking out a victory against the Baker Mayfield-inspired Carolina Panthers? As revenge games go, it was underwhelming. The hefty 6½-line for this point spread has a lot more to do with how badly the Jets played in Week 1, but apparently Robert Saleh’s side is taking receipts for all the doubters. Time to put up, no?

PICK: Jets +6½ (-110)

  • Commanders vs Lions
    Sunday, 1 p.m. ET, FOX

This isn’t a typo! The Detroit Lions are favored for the first time in forever! The Lions are coming off a loss but showed some fight-back late in the game. This is a winnable game for the Lions, even though they’re facing a Washington side that’s buoyed by a come-from-behind win against the Jaguars. It’s the “come-from-behind” bit against the Jags that has us on the fence with the Commanders in this Week 2 road game.

PICK: Lions -1 (-115)

  • Buccaneers -2½ vs Saints
    Sunday, 1 p.m. ET, FOX

Tom Brady and the Bucs are due a win over the Saints in the regular season, surely.

PICK: Buccaneers -2½ (-115)

  • Panthers vs Giants
    Sunday, 1 p.m. ET, FOX

The Giants had no business winning against the Tennessee Titans in Week 1. Had Randy Bullock threaded the 47-yard, game-winning field goal attempt in the dying seconds, then everyone would be thinking it’s the same ol’ Giants again and head coach Brian Daboll wouldn’t be the toast of the town that he was this week.

PICK: Panthers +1 (+105)

  • Patriots vs Steelers
    Sunday, 1 p.m. ET, CBS

Mac Jones is cleared to play, but will he be able to lead the Patriots to victory at Acrisure Stadium? The Steelers threw down the gauntlet by beating the Cincinnati Bengals in Week 1. It wasn’t pretty, but it was a complete team effort. Could the Steelers be the surprise 2-0 SU team at the end of this weekend?

PICK: Steelers +1

  • Colts vs Jaguars
    Sunday, 1 p.m. ET, CBS

The Indianapolis Colts very nearly lost to the Houston Texans in Week 1 and the Jacksonville Jaguars came close to pulling off the upset in the nation’s capital in the same week. It’s too early to get a true sense of both teams, but the Jaguars are in a position to deliver the big upset at home over the overrated Colts.

PICK: Jaguars +3½ (-105)

  • Dolphins vs Ravens
    Sunday, 1 p.m. ET, CBS

Lamar Jackson and the Ravens will be keen to get their revenge over the Miami Dolphins after losing to them last season at Hard Rock Stadium. Expect Jackson and Co. to deliver and cover as the firm home favorites.

PICK: Ravens -3½ (-110)

  • Falcons vs Rams
    Sunday, 4:05 p.m. ET, FOX

The Rams aren’t as bad as their 31-10 loss to the Buffalo Bills in Thursday Night Football suggested, while the Falcons might be better than preseason markets gave them credit. The Rams should win this game, but laying 10 points with them feels like too many points, even against the Falcons.

PICK: Falcons +10

  • Seahawks vs 49ers
    Sunday, 4:05 p.m. ET, FOX

The Seahawks thwarted Russell Wilson’s homecoming by beating the Denver Broncos 17-16, marking one of the biggest upsets of Week 1. The Niners were dealt an upset by the Chicago Bears, losing 19-10 in the Windy City. Pete Carroll’s side has dominated the Niners in recent history, including a series sweep. Might there be another big upset on the cards here? Put it this way, it’ll take a brave bettor to trust Trey Lance’s Niners to cover two scores right now.

PICK: Seahawks +10 (-130)

  • Bengals vs Cowboys
    Sunday, 4:25 p.m. ET, CBS

The season may well be over before it even got started in Jerry’s World. With Dak Prescott out, due to a hand injury, the Cowboys will be fielding backup Cooper Rush in his stead. Enough said.

PICK: Bengals -7½

  • Texans vs Broncos
    Sunday, 4:25 p.m. ET, CBS

Either the bookmakers didn’t watch Monday Night Football or we’re missing something. Russell Wilson and the Broncos should win their season home opener, but nothing about their haphazard Week 1 defeat to the Seahawks suggests they’re a good bet to cover as the -10 home chalk.

PICK: Texans +10

  • Cardinals vs Raiders
    Sunday, 4:25 p.m. ET, CBS

Perhaps, the biggest knee-jerk reaction is the NFL betting markets’ response to the Cardinals’ 44-21 loss to the Chiefs. It’s the Chiefs! Yes, it was a lopsided defeat, but at the sake of sounding repetitive, it’s the Chiefs!

PICK: Cardinals +5½

  • Bears vs Packers (-10)
    Sunday, 8:20 p.m. ET, NBC

Aaron Rodgers owns shares in the Chicago Bears and after last week’s humiliation in Minnesota, look for the Packers to steamroll Justin Fields and Co. at Lambeau.

PICK: Packers -10 (-110)

  • Titans vs Bills
    Monday, 7:15 p.m. ET, CBS

The Bills will have been on ice for almost 12 days since Thursday’s 31-10 win over the Rams. That’s a lot of time to cool off. In the meantime, the Titans are hot under the collar after losing a winnable game against the Giants. So, they’ll be keen to bounce back in Week 2, even though the odds are heavily stacked against them. The Titans have had the measure of the Bills, beating them twice since 2020. Take the points with the Titans.

PICK: Titans +10 (-110)

  • Vikings vs Eagles
    Monday, 8:30 p.m. ET, CBS

The Vikings are possibly the most underrated team whereas the Eagles are possibly the most overrated team. Expect the true colors of these outfits to be revealed in this fascinating MNF tilt.

PICK: Vikings +1

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