We’re back with our selection of NFL ATS bets for Week 2 in this weekly column. This week brings some daunting double-digit point spreads, quite a few tight lines, several pivotal divisional contests and a handful of teams looking to bounce back after horrendous debuts.
Who will win and/or cover for NFL picks against the spread?
Read on for our game preview and quick-fire NFL predictions below, which include the latest stats, injury reports and NFL odds, capped off with choice NFL picks for your consideration.
NFL Week 2 ATS Predictions & Picks
- Jets (+6½) vs Browns
Sunday, 1 p.m. ET, CBS
Do the Cleveland Browns merit praise for eking out a victory against the Baker Mayfield-inspired Carolina Panthers? As revenge games go, it was underwhelming. The hefty 6½-line for this point spread has a lot more to do with how badly the Jets played in Week 1, but apparently Robert Saleh’s side is taking receipts for all the doubters. Time to put up, no?
PICK: Jets +6½ (-110)
- Commanders vs Lions
Sunday, 1 p.m. ET, FOX
This isn’t a typo! The Detroit Lions are favored for the first time in forever! The Lions are coming off a loss but showed some fight-back late in the game. This is a winnable game for the Lions, even though they’re facing a Washington side that’s buoyed by a come-from-behind win against the Jaguars. It’s the “come-from-behind” bit against the Jags that has us on the fence with the Commanders in this Week 2 road game.
PICK: Lions -1 (-115)
- Buccaneers -2½ vs Saints
Sunday, 1 p.m. ET, FOX
Tom Brady and the Bucs are due a win over the Saints in the regular season, surely.
PICK: Buccaneers -2½ (-115)
- Panthers vs Giants
Sunday, 1 p.m. ET, FOX
The Giants had no business winning against the Tennessee Titans in Week 1. Had Randy Bullock threaded the 47-yard, game-winning field goal attempt in the dying seconds, then everyone would be thinking it’s the same ol’ Giants again and head coach Brian Daboll wouldn’t be the toast of the town that he was this week.
PICK: Panthers +1 (+105)
- Patriots vs Steelers
Sunday, 1 p.m. ET, CBS
Mac Jones is cleared to play, but will he be able to lead the Patriots to victory at Acrisure Stadium? The Steelers threw down the gauntlet by beating the Cincinnati Bengals in Week 1. It wasn’t pretty, but it was a complete team effort. Could the Steelers be the surprise 2-0 SU team at the end of this weekend?
PICK: Steelers +1
- Colts vs Jaguars
Sunday, 1 p.m. ET, CBS
The Indianapolis Colts very nearly lost to the Houston Texans in Week 1 and the Jacksonville Jaguars came close to pulling off the upset in the nation’s capital in the same week. It’s too early to get a true sense of both teams, but the Jaguars are in a position to deliver the big upset at home over the overrated Colts.
PICK: Jaguars +3½ (-105)
- Dolphins vs Ravens
Sunday, 1 p.m. ET, CBS
Lamar Jackson and the Ravens will be keen to get their revenge over the Miami Dolphins after losing to them last season at Hard Rock Stadium. Expect Jackson and Co. to deliver and cover as the firm home favorites.
PICK: Ravens -3½ (-110)
- Falcons vs Rams
Sunday, 4:05 p.m. ET, FOX
The Rams aren’t as bad as their 31-10 loss to the Buffalo Bills in Thursday Night Football suggested, while the Falcons might be better than preseason markets gave them credit. The Rams should win this game, but laying 10 points with them feels like too many points, even against the Falcons.
PICK: Falcons +10
A killer photo of Roquan Smith putting Trey Lance’s face in the mud.
That about sums up the Bears/49ers game.
(via @PFF) pic.twitter.com/yGKmYbCdir
— Ryan Heckman (@TheRyanHeckman) September 12, 2022
- Seahawks vs 49ers
Sunday, 4:05 p.m. ET, FOX
The Seahawks thwarted Russell Wilson’s homecoming by beating the Denver Broncos 17-16, marking one of the biggest upsets of Week 1. The Niners were dealt an upset by the Chicago Bears, losing 19-10 in the Windy City. Pete Carroll’s side has dominated the Niners in recent history, including a series sweep. Might there be another big upset on the cards here? Put it this way, it’ll take a brave bettor to trust Trey Lance’s Niners to cover two scores right now.
PICK: Seahawks +10 (-130)
- Bengals vs Cowboys
Sunday, 4:25 p.m. ET, CBS
The season may well be over before it even got started in Jerry’s World. With Dak Prescott out, due to a hand injury, the Cowboys will be fielding backup Cooper Rush in his stead. Enough said.
PICK: Bengals -7½
- Texans vs Broncos
Sunday, 4:25 p.m. ET, CBS
Either the bookmakers didn’t watch Monday Night Football or we’re missing something. Russell Wilson and the Broncos should win their season home opener, but nothing about their haphazard Week 1 defeat to the Seahawks suggests they’re a good bet to cover as the -10 home chalk.
PICK: Texans +10
- Cardinals vs Raiders
Sunday, 4:25 p.m. ET, CBS
Perhaps, the biggest knee-jerk reaction is the NFL betting markets’ response to the Cardinals’ 44-21 loss to the Chiefs. It’s the Chiefs! Yes, it was a lopsided defeat, but at the sake of sounding repetitive, it’s the Chiefs!
PICK: Cardinals +5½
- Bears vs Packers (-10)
Sunday, 8:20 p.m. ET, NBC
Aaron Rodgers owns shares in the Chicago Bears and after last week’s humiliation in Minnesota, look for the Packers to steamroll Justin Fields and Co. at Lambeau.
PICK: Packers -10 (-110)
Tennessee #Titans QB Ryan Tannehill dropped in this dime to give Tennessee a chance to overcome the New York #Giants. Unfortunately for them, the field goal was no good #Touchdown #NFL #Tennessee #Sports #Nashville #TitanUp pic.twitter.com/o4yfIeZATl
— Win Big Sports (@WBSNsports) September 12, 2022
- Titans vs Bills
Monday, 7:15 p.m. ET, CBS
The Bills will have been on ice for almost 12 days since Thursday’s 31-10 win over the Rams. That’s a lot of time to cool off. In the meantime, the Titans are hot under the collar after losing a winnable game against the Giants. So, they’ll be keen to bounce back in Week 2, even though the odds are heavily stacked against them. The Titans have had the measure of the Bills, beating them twice since 2020. Take the points with the Titans.
PICK: Titans +10 (-110)
- Vikings vs Eagles
Monday, 8:30 p.m. ET, CBS
The Vikings are possibly the most underrated team whereas the Eagles are possibly the most overrated team. Expect the true colors of these outfits to be revealed in this fascinating MNF tilt.
PICK: Vikings +1
