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NFL Betting Predictions: The Top AFC Favorites In Week 16 Revealed

Okay BetUS NFL online betting faithful, the Cleveland Browns will look to keep the good times rolling when they visit the lowly Cleveland Browns on Sunday!

In Baltimore, the Ravens will look to improve their chances of reaching the playoffs when they play host to the struggling New York Giants. Last, but not least, the red-hot Buffalo Bills will look to complete their regular-season sweep of the division rival New England Patriots.

Baker Mayfield

If you’re looking for Week 16 NFL sportsbook betting favorites, then you’ve come to the right place. Before we get started, let’s check out all of the Week 16 NFL Odds!!

Cleveland (10-4) at NY Jets (1-13)

When: Sunday, 1 p.m. ET
Where: MetLife Stadium, East Rutherford, NJ
NFL Odds: Cleveland -10
Moneyline: Browns -470/Jets +370
Total: 47½

The Browns are playing their best football at the right time. Cleveland has won five of six including a 20-6 smackdown of the New York Giants on Sunday. Cleveland has put 41 points or more on the board in two of three while limiting two of its last six opponents to a touchdown or less.

It’s a damned shame, but the New York Jets can’t even win at losing! The Jets blew their golden opportunity for the No. 1 overall pick by upsetting an LA Rams team with playoff hopes, 23-20 on Sunday.


While the Jets pulled off arguably the season’s biggest upset last weekend, I certainly don’t see another stunner going down in this Week 16 mismatch. I know the Browns are 3-10 ATS in their last 13 road games and 1-6 ATS in their last seven road games, but I don’t think it’s going to matter much in this Week 16 pairing.

New York might be an impressive  9-3-1 ATS in its last 13 home games against a team with a winning road record, but the favorite in this AFC series is a near-perfect 10-1 ATS in the last 11 meetings.

The Jets don’t want to win this game no matter what they’re saying while the Browns want to keep their momentum going before the playoffs. I see a huge spanking just waiting to happen NFL betting buffs!

(Update: This was written before it was learned the Browns would be without numerous WRs due to COVID-19 protocols).

Pick: Browns 38, Jets 10

Here is a look at the latest NFL division title odds

NY Giants (5-9) at Baltimore (9-5)

When: Sunday,1 p.m. ET

Where: MT Bank Stadium, Baltimore, MD
NFL Odds: Baltimore -10½
Moneyline: Giants +400/Ravens -500
Total: 43½

The Giants have dropped two straight and come into this matchup fresh off a humbling 20-6 home loss against the streaking Browns on Sunday. The G-Men have been limited to a paltry 13 combined points the last two weeks and looks like a deflated team at this point.

Conversely, Baltimore has won three straight to keep their playoff hopes alive including an emphatic 40-14 blowout of Jacksonville last weekend. Baltimore has put at least 34 points on the board in three straight. Lamar Jackson has six TD passes and two interceptions over the last three games while rushing for 253 yards and four additional scores.


The Giants are 7-3 ATS in their last 10 following a straight-up loss while Baltimore have gone a perfect 4-0 ATS in its last four games and a stellar 8-0 ATS in its last eight games in the month of December.

If the double-digit spread looks a bit daunting, I wouldn’t worry about it too much. I’m fully expecting the Ravens to win this Week 16 interconference clash by at least two touchdowns!

Pick: Ravens 31, Giants 10

Check out the latest NFL Conference Championship Odds!

Buffalo (7-2) at New England (5-3)

When: Monday, 8:15 p.m. ET

Where: Gillette Stadium, Foxboro, MA
NFL Odds: Buffalo -7
Moneyline: Buffalo -310/New England +260
Total: 46

Buffalo has won four straight games in increasingly impressive fashion including their 48-19 smackdown of Denver on Sunday. Quarterback Josh Allen has blossomed into a legitimate star while throwing eight TD passes and only one interception in the last three games. Buffalo has put at least 26 points on the board in four straight while limiting the opposition to 19 points or less in three of their last four.

New England has lost two straight and three of five including a humbling 22-12 road loss against Miami last weekend. The Patriots have scored a grand total of 15 points the last two weeks and lost to Buffalo 24-21 in Week 10.


Buffalo has gone 6-0 ATS in its last six games and 11-4-2 ATS in its last 17 road games. The Patriots are 1-3-1 ATS in their last 5 games in December while the road team in this AFC East rivalry has gone 21-8-2 ATS in the last 31 meetings. Even on the road, Buffalo looks like a virtual lock to cover the 7½ -point spread!

Pick: Bills 27, Patriots 17

Here is a look at the latest Super Bowl Odds

Three-Team Parlay Payout

Cleveland -470
Baltimore -500
Buffalo -310
Payout: $92.48

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