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NFL Week 1 O/U Plays of the Week

Chargers, Bucs, Chiefs To Light Up

NFL Week 1 is underway finally. The Buffalo Bills got proceedings going with a resounding 31-10 win over the defending Super Bowl champions Los Angeles Rams at SoFi Stadium on Thursday Night Football.

So, with one game in the books, it raises the question about the rest of the week and how it might unfold. Simply, Where are the value bets to be had?

Week 1 Overs
Mike Ehrmann/Getty Images/AFP

In this space, we’ll run down through the NFL schedule and examine the totals in betting online markets. The purpose is to determine whether the OVER or the UNDER is the best play.

Read on for our game preview and quick-fire NFL predictions below, which include the latest stats, injury reports, NFL odds and are capped off with choice NFL picks for your consideration.

NFL Week 1 O/U Predictions & Picks

  • Baltimore Ravens vs  New York Jets – O/U 44
    Sunday, 1 p.m. ET, CBS

Lamer Jackson will go head-to-head with his former teammate Joe Flacco, the quarterback he replaced in Baltimore. This game for NFL picks SU and ATS, feels like it could be a right-cracking matchup.

Pick: OVER 44 (-110)

  • Jacksonville Jaguars vs Washington Commanders – O/U 44
    Sunday, 1 p.m. ET, FOX

Will Trevor Lawrence fulfill his promise with Doug Pederson as his head coach? He certainly might as the former Eagles frontman knows a thing or two about developing young talent, having been present for the maturation of Carson Wentz in Philly. It’s not without some irony that Pederson and Wentz will be squaring up against each other with their new teams in the first week.

Pick: Over 44 (-110)

  • Kansas City Chiefs vs Arizona Cardinals – O/U 53½
    Sunday, 4:25 p.m. ET, CBS

Whenever Patrick Mahomes and the Chiefs take to the field, one expects plenty of fireworks, offensive football, and truckloads of touchdowns being scored. Kyler Murray just got his payday and he’ll be keen to prove himself against one of the game’s best, even if only to highlight the fact that he’s just as elite as Mahomes is. Murray will be challenged without DeAndre Hopkins, but the Cardinals’ offense is multi-dimensional and Kliff Kingsbury should have a few plays up his sleeve that will push this total OVER the NFL line currently on offer.

Pick: OVER 53½ (-110)

  • Las Vegas Raiders vs Los Angeles Chargers – O/U 52
    Sunday, 4:25 p.m. ET, CBS

This game has fireworks written all over it. If Derek Carr and Justin Herbert live up to their credentials, there should be plenty of scoring, momentum shifts, and drama in this reprisal of that fateful AFC West showdown that crushed Los Angeles’ playoff hopes and sent the Raiders into the postseason.

Pick: OVER 52 (-110)

  • Tampa Bay Buccaneers vs Dallas Cowboys – O/U 50½
    Sunday, 8:2 p.m. ET, NBC

This is another game that has all the hallmarks of being a right shootout between high-powered offenses. Last season, the pair delivered a 60-point thriller in Tampa Bay, which the Buccaneers won on a last-gasp field goal. Both sides come into this game with significant changes on the offensive side of the ball. Rob Gronkowski and Antonio Brown are no longer on the roster while the Cowboys sent Amari Cooper packing. This is still likely to be a high-scoring game, but it might come just under the total.

Pick: UNDER 50½  (-110)

The Rest of Week 1 In Quick Fire NFL Picks

  • Philadelphia Eagles vs Detroit Lions O/U 48½ – Pick Over 48½
  • New Orleans Saints vs Atlanta Falcons O/U 43 – Pick: Over 43
  • San Francisco 49ers vs Chicago Bears O/U 40½  – Pick: Over 40½
  • Pittsburgh Steelers  vs Cincinnati Bengals O/U 44½ – Pick: Under 44½
  • New England Patriots vs Miami Dolphins O/U 46½. – Pick Under 46½
  • Cleveland Browns vs Carolina Panthers  O/U 42 – Pick: Under 42
  • New York Giants vs Tennessee Titans O/U 44 – Pick Under 44
  • Indianapolis Colts  vs Houston Texans O/U 46 – Pick: Under 46
  • Green Bay Packers vs Minnesota Vikings O/U 46½ – Pick Over 46½
  • Denver Broncos vs Seattle Seahawks O/U 44 – Pick Under 44

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