NFL Week 17 Best Over/Under Bets – Game-by-Game Predictions

Read on for our breakdown of the week’s slate of games, starting with Sunday’s jam-packed schedule and concluding with Monday Night Football between the Buffalo Bills and Cincinnati Bengals.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines. We’ve plenty of Vegas NFL odds and NFL week 17 picks for you to consider.

NFL Odds: Week 17 O/U Predictions & Picks

Colts vs Giants

Sunday, 1 p.m. ET, CBS

Daniel Jones and the G-men could punch their playoff ticket with a win over the Indianapolis Colts this weekend. The Colts have moved on from Matt Ryan to Nick Foles, but the former Super Bowl MVP was largely ineffective in a 20-3 loss to the Los Angeles Chargers on Monday. Foles will likely play better in his second start (hope springs eternal). But will it be enough? Somehow, it’s hard to see Foles bettering this gritty Giants team that doesn’t know how to quit. Overall, this has the hallmarks of a low-scoring game between two outfits that put a lot of stock in their defenses.

• Pick: Under 39 (-110)

Browns vs Commanders

Sunday, 1 p.m. ET, FOX

Washington’s quarterback conundrum is an interesting one, especially as it comes so late in the season. However, regardless of his decision, be it to go with Taylor Heinicke or return to Carson Wentz, the Commanders are in better shape overall than the Browns. Cleveland’s offense has regressed ever since it handed the keys to Deshaun Watson. They’re punchless, clueless, and wholly of color.

• Pick: Under 40½ (-110)

Jets vs Seahawks

Sunday, 4:05 p.m. ET, FOX

The Jets offense is poised to make a comeback behind Mike White after taking a brief hiatus under Zach Wilson, and against a porous Seahawks defense, White should face little resistance. In the meantime, the Seahawk’s offense, at one point one of the more potent in the league, has gone walkabout in recent weeks. Whether they find form again will depend largely on the Jets’ elite defense. Will it show up in this game? It didn’t last week against the Jaguars, falling meekly behind a 19-3 loss to the visitors instead.

• Pick: Over 42 ½ (-110)

Vikings vs Packers

Sunday, 4:25 p.m. ET, CBS

The Vikings’ offense is firing on all cylinders. Kirk Cousins is playing lights out and the O-line is scoring in abandon. The Vikings’ offense ranks seventh overall, with 25.2 points per game this season. In the last three weeks, they’ve averaged 29.7 ppg. Unfortunately, they’re not getting a lot of help from their defense, which is allowing 24.9 ppg on average this season and a whopping 31.3 ppg in their last three. With Aaron Rodgers and the Packers fighting for their playoff hopes, this will be one of the week’s marquee billings to spot. Importantly, Rodgers is starting to get comfortable with his young offensive line, and they’re playing with conviction. That’s nowhere more evident than in the scoring, which stands at 26 ppg in their last three games, up from a seasonal average of 20.9 ppg.

• Pick: Over 48 (-110)

Rams vs Chargers

Sunday, 4:25 p.m. ET, CBS

Justin Herbert ranks third overall among passers in the league, passing for 4,254 yards, 21 touchdowns, and 10 interceptions. The Chargers offense is scoring an average of 22.1 ppg. But the recent surge in their defense is dictating the outcome of games. This unit tops the league with 11.3 ppg allowed in the last three weeks, marginally better than the No. 1 ranked Niners defense that has allowed 13.3 ppg over this same period. That doesn’t bode well for Baker Mayfield, who has struggled under pressure in the past. The Rams’ defense is no slouch either, allowing just 18 ppg in its last three outings, down from a season average of 22.3 ppg.

• Pick: Under 42½ (-110)

Steelers vs Ravens

Sunday, 8:20 p.m. ET, NBC

The Pittsburgh Steelers rank amongst the top-scoring defenses with 14.3 ppg allowed in the last three weeks. On the season, they rank 13th overall with 21.3 ppg. That will be key in a matchup against a Ravens defense that sits third overall with 18.1 ppg and second in the last three weeks with 12.0 ppg. By these stats, there’s no mistaking the strength of these AFC North rivals is in the D-unit. Of course, that could change if Lamar Jackson starts in Week 17 versus the Steelers. Jackson would turn the focus on offense, putting pressure on rookie Kenny Pickett and the O-line to respond in kind. As of the time of writing, however, it looks more likely that Tyler Huntley will get another crack at it. The Ravens’ offense has managed just 12 ppg under the backup. The Steelers, by contrast, are averaging 17.6 ppg this season. All things being considered, this game appears to be a great candidate for the underbet. But the case for the over could be made with the total line set to a very low 35 points.

• Pick: Over 35 (-110)

Bills vs Bengals

Monday, 8:15 p.m. ET, ESPN

If both these teams and their elite quarterbacks live up to the billing, this should be a high-scoring affair to cap off the week. Josh Allen and Joe Burrow are among the Top 5 passers in the league, mired in the MVP race. The offensive weapons in both camps are a coach’s envy. There’s no reason why these two teams can’t go toe-to-toe in scoring. Buffalo is scoring 28 ppg on average, while Cincy is putting up 26.1 ppg on average. The defenses here are also aggressive and attacking-minded, making them a potential secondary source of scoring. Don’t overthink this one and back the over. Color the world shocked if it doesn’t crack the total. High though it is.

• Pick: Over 49 ½ (-110)

Quick-Fire NFL Picks: The Rest of Week 16 Games

• Cardinals vs Falcons, O/U 42 – Pick: Under 42 (-110)
• Bears vs Lions, O/U 52 – Pick: Over 52 (-110)
• Broncos vs Chiefs, O/U 45 – Pick: Over 45 (-110)
• Dolphins vs Patriots, O/U 41 – Pick: Over 41 (-110)
• Saints vs Eagles, O/U 42 – Pick: Over 42 (-110)
• Panthers vs Buccaneers, O/U 40½ – Pick: Under 40½ (-110)
• Jaguars vs Texans, O/U 43 ½ – Pick: Over 43½ (-110)
• 49ers vs Raiders, O/U 42 – Pick: Over 42 (-110)