Patriots vs Bills Prediction and NFL Player Props for Week 16: TD Bets That Get Increasingly Hotter Dec 22
- Get the best Patriots vs Bills odds at BetUS.
- A pair of running backs can earn their backers profit in a potential blowout
- Our expert NFL player prop picks also list an underrated red zone threat for Buffalo
The Bills and Patriots clash in a game where touchdowns could come from anywhere, and we’re here to dig into the best NFL prop bets for this matchup. From New England’s workhorse Rhamondre Stevenson to Buffalo’s underrated red-zone star Mack Hollins, we’ve lined up TD props with solid value. But buckle up—our picks only get bolder as we go, with a wild-card selection that could hit big if the game turns into a blowout!

Patriots vs Bills Game Information
- Game: Patriots (3-11) vs Bills (11-3)
- Date/Time: Sunday, Dec 22, 4:25 pm ET
- Location: Highmark Stadium, Orchard Park, NY
- Patriots vs Bills Live Stream: NFL Game Pass
Patriots vs Bills Odds and Spreads


Place Your Bets On Patriot vs Bills At BetUS Sportsbook!
3 Top Patriots vs Bills TD Props for Dec 22
1. Patriots RB Rhamondre Stevenson 1+ TD (+160)
Stevenson, not Drake Maye, is the Patriots’ go-to guy on offense. We saw that play out against Arizona when Jerod Mayo elected to give him the ball in short-yardage situations even if his young QB is built like Josh Allen. This won’t change even with Maye saying something about it. Thus, Stevenson has one of the better NFL touchdown props here.
The Patriots FIRST TD of the 2024 regular season.
Rhamondre Stevenson. 🔥🔥 pic.twitter.com/RM3nC5BPdt
— Pats Buzz (@PatsBuzz) September 8, 2024
The fourth-year pro has seven touchdowns for the season and all but one came within five yards of the endzone. New England can run the ball against a Bills team that gives up 4.7 rushing yards per carry and 121+ yards in four of their last six games.
The Patriots rank 30th in red-zone touchdown rate (46.3%) and Stevenson has yet to score in four career games against Buffalo. But we like the NFL odds here. He’s still the Pats’ lead back in a run-heavy style against a wide favorite that may be half-asleep for half this game—Bet Stevenson to score.
Bet On Rhamondre Stevenson 1+ TD (+160)
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2. Bills WR Mack Hollins 1+ TD (+500)
The weirdest guy in the NFL has been a money-maker for anyone brave enough to bet him to score. But at his current price, we don’t need to be that brave as he’s proven to be a dependable red-zone target for Buffalo. Hollins has scored five touchdowns for Buffalo (a career-high), all from 21 yards or shorter.
Only Khalil Shakir has been a better target inside the 20 among receivers. Keon Coleman has been too banged-up while Amari Cooper has not even been targeted (we had to check this twice). Curtis Samuel is another sneaky bet to score if it’s a blowout and he gets extra reps.
But for our money, Hollins is the best bet online considering we’re getting 5/1 on a player who is pretty much Buffalo’s top cherry-picker.
Bet On Mack Hollins 1+ TD (+500)
3. Bills RB Ray Davis 2+ TDs (+1200)
Speaking of the red zone, why not sprinkle some on Davis? Buffalo’s RB2 could be in for a big day if it’s a blowout and the coaches choose to let him carry the load late in the game. Davis has quietly been playing like a starter with the limited touches he’s gotten. He’s also scored in four of his last seven games where he got snaps.
Ray Davis takes it in for the TD! Time for snowballs in Buffalo ☃️
📺: #SFvsBUF on NBC/Peacock
📱: Stream on #NFLPlus pic.twitter.com/Mny7SZpama— NFL (@NFL) December 2, 2024
We can bet on Cook to score a pair of TDs at +300 or even Josh Allen at +350. These are not bad NFL game predictions. But in a potential blowout, Davis will get more looks. He got 11 carries in Buffalo’s 35-10 win over San Francisco. He got six in the 31-10 rout over Seattle.
At 11/1, it’s worth a dart throw for Davis to have his first multi-TD game, especially since he’s proven he can capitalize on opportunities in garbage time and against worn-down defenses, making this a high-value bet with big upside potential.
Bet On Ray Davis – 2+ TDs (+1200)
More Patriots vs Bills Week 16 Bets and Picks
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
Question of the Day
Which Buffalo Bills player has scored the most touchdowns this season?
Bills running back James Cook leads his team with 14 touchdowns from rushing or receiving.