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Rams vs 49ers TNF Parlay Picks: Bet on Deebo Samuel to Deliver December 12

 

Our NFL game predictions have been consistently successful this season, guiding our audience to significant profits. We’re here and ready to continue this momentum with the exciting Thursday Night Football clash between the Los Angeles Rams and San Francisco 49ers.

Rams vs 49ers TNF Parlay Picks: Bet on Deebo Samuel to Deliver 1
Deebo Samuel Sr. #1 of the San Francisco 49ers / Stacy Revere / Getty Images North America / Getty Images via Afp

I have meticulously reviewed all the NFL odds and have assembled a three-leg parlay. While you could certainly do a ton of your own research, the beauty is that we’ve already done that legwork for you.

Let’s dive into my top TNF parlay picks.

 

Rams vs 49ers Game Information

  • Game: San Francisco 49ers (6-7) vs. Los Angeles Rams (7-6)
  • Location: Levi’s Stadium, Santa Clara, CA
  • Date/Time: Dec. 12, 8:15 p.m. ET
  • 49ers vs. Rams Live Stream: Amazon Prime Video

 

Make sure to check updated 49ers vs Rams injuries before placing your bets.

 

Rams vs 49ers Odds and Spreads

Rams
49ers
+2 Ev
Spread
-2 -120
+122
Moneyline
-142
O 48½ -110
Total
U 48½ -110

Place your Bets on Rams vs 49ers at BetUS Sportsbook!

 

My Top 3 TNF Parlay Picks for 49ers vs. Rams

1. 49ers WR Deebo Samuel to Score a Touchdown

The first leg of our Thursday Night Football same-game parlay bet will be a Deebo Samuel anytime touchdown. The 49ers wide receiver has taken a significant step back in production this season, but he is primed for a big game. Samuel shared on social media following the 49ers’ Week 14 win that he’s “not struggling at all just not getting the ball.”

This is a classic case of the squeaky wheel getting the grease. His teammate, George Kittle, responded when speaking to the media on Tuesday. “Deebo’s very close to breaking it wide open. I’m very excited for him this Thursday because I think he’s going to have one of those amazing Deebo Thursday Night games,” Kittle said.

Kyle Shanahan will dial up plenty of calls on the play sheet to get Samuel involved early and often. Samuel has found the end zone in all three of his last Thursday Night Football appearances. Expect a vintage Deebo game.

Bet on Deebo Samuel Anytime Touchdown (+140)

 

Touchdown Profits! Bet $200, Get $450 Bonus on first time deposit.

 

2. 49ers WR Deebo Samuel Over 49½ Receiving Yards

The second NFL expert pick for our TNF parlay will be for Deebo Samuel to go over his receiving yards.

You know who I wouldn’t want to be this weekend? Someone who has anything to do with the Rams’ defense. The San Francisco 49ers will play extremely ticked off with NFL pundits counting out the defending NFC champs.

The Rams’ defense has been below-average against the pass. Per Rams vs 49ers stats, Los Angeles ranks 25th in defensive success rate (42.3%) and in the bottom six in yards allowed per reception (11.4), yards allowed per coverage snap (6.95), and yards allowed per coverage target (8.7).

Wide receivers have gone bonkers against this defense. Last week, we watched Buffalo’s Khalil Shakir post 106 yards on five grabs. Deebo is having a mediocre season by his standards but should add a big day on Thursday night.

The Rams play zone at a top-five rate, and Deebo has eaten up defenses that run zone throughout his career. Samuel has exceeded this line in six of his last seven games against the Rams. In his last four Thursday night appearances, Deebo has finished with 102, 79, 129, and 159 receiving yards.

I expect the Niners to bully the Rams defense around the yard, and Samuel will lead the way on this night.

Bet on Deebo Samuel over 49.5 receiving yards (-114)

3. 49ers Moneyline (-140)

The final NFL bet today to include in this parlay will be for the 49ers to win this game. The Rams are traveling on a short week and are coming off their most emotional win of the season. They went back and forth on Sunday and outlasted Josh Allen and the Buffalo Bills 44-42 in the highest-scoring game of the 2024 NFL season.

However, this leads us to believe they could be primed for a letdown. The 49ers will do their best to bully the Rams on a physical level after they managed to coast by the Bears just four days ago. The Rams’ defense has the fourth-worst EPA per dropback allowed, so Brock Purdy should carry his momentum from the 325-yard, two-touchdown showing in Week 14.

The betting public is backing the Rams as road underdogs, but this line suggests that the 49ers, with a worse record, are the correct side. Despite their laundry list of injuries, San Francisco has a better EPA per play and is seventh in team total DVOA.

The Rams rank 17th in team total DVOA. Kyle Shanhan’s Niners are 9-5 straight up when playing a team they lost to earlier in the season. My last NFL prediction is to ride with the 49ers with the final leg of this parlay.

Bet This Pick: 49ers ML (-140)

 

Questions of the Day

What is the best NFL bet for Thursday night?


Deebo Samuel to go over his receiving yards is the best bet on Thursday night.

What is the best NFL parlay leg for Thursday?


The best NFL parlay leg for Thursday Night Football is the 49ers to win.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.

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