The Kansas City Chiefs currently lead the NFL in terms of odds of winning the Super Bowl at +325. But, with four teams sporting odds of 5/1 or shorter, the Chiefs are lukewarm favorites at best.
The Bills, Eagles, 49ers, Eagles, and Bengals are considered the most likely teams to go all the way, but there isn’t a lot separating them.
To make finding the best bet easier, let’s dig into each of the top five favorites and their strengths and weaknesses.
Let’s check the latest NFL odds, stats, injury reports, and NFL lines. We’ve plenty of Vegas NFL odds for NFL Wild Card Playoffs Games.
Kansas City Chiefs (+325 to Win Super Bowl)
The Kansas City Chiefs earned the No. 1 seed in the AFC with a 14-3 record in the regular season. They finished the season on a five-game winning streak and have an opening-round bye as a result. They kick off their postseason at home in the divisional round.
The biggest issue for the Chiefs from where we sit is the potential for a second game against the Bengals this season.
The Bengals not only knocked the Chiefs out of the playoffs last year, but they beat them 27-24 in Week 13 in what was supposed to be a redemption game for KC. The Chiefs enter the playoffs on an 0-3 slide against Cincy. Their path to the Super Bowl may also see them up against Buffalo, which beat them 24-20 in Week 6. A potential game between the Bills and Chiefs in the AFC Championship would take place at Atlanta’s Mercedes-Benz Stadium.
With an 0-2 record against the other two hopefuls from the AFC this season, the Chiefs are a risky favorite to wager on.
Buffalo Bills (+400 to Win Super Bowl)
The Bills finished the regular season with a win over the New England Patriots, their seventh in a row, to end up at 13-3. With the No. 2 seed in the AFC, the Bills kick off their playoff run against their division-rival Miami Dolphins on Sunday.
Their odds are high, considering the Dolphins beat Buffalo 21-19 in Week 3 and nearly went 2-0 in the season series after a 32-29 loss in Week 15. With such close games between the two, the Bills’ most challenging game may be their first.


San Francisco 49ers (+475 to Win Super Bowl)
The San Francisco 49ers enter the playoffs on a 10-0 run and are the hottest team in the NFL, hands down. The Niners notched their 10th straight on Sunday with a big-boy win over the Cardinals 38-13.
They finished the season with a league-leading +173 point differential and face the Seattle Seahawks on Saturday in the opening round.
Despite the 49ers’ end to the year, the team is a bit of a Cinderella story, thanks to its quarterback issues. Both the 49ers’ starters were knocked out, and they were left with the last pick in the 2022 NFL Draft, Brock Purdy, to handle quarterbacking duties for a Super Bowl favorite. Expectations were low until Purdy took the field and lit up the scoreboard.
Philadelphia Eagles (+500 to Win Super Bowl)
The Eagles were the best team in the NFL through the first 15 weeks of the season, with a 13-1 record after losing Week 10 to the Washington Commanders. However, their season began to fall apart; starting QB Jalen Hurts was injured, and the Eagles finished the season 1-2.
But the Eagles finished the season with a win, thanks to the return of Hurts against the Giants on Sunday. They get the weekend off to plan, thanks to finishing No. 1 in the NFC. This is big news for Hurts’ shoulder, and the star QB will have an extra seven days to rest up for the divisional round.
Cincinnati Bengals (+650 to Win Super Bowl)
Joe Burrow led the Bengals to a 12-4 record and an 8-0 run to finish the season. Burrow has also led the Bengals to three straight wins over Mahomes and the Chiefs. While they have some work to do in the opening round against the Ravens on Sunday night, we like their chances should they come up against the Super Bowl favorites again.


Dark Horses Worth a Look
One of the more exciting teams outside of the top five in the NFL odds is the Tampa Bay Buccaneers (+2000). This may be Tom Brady’s last trip to the postseason, and we have been wrong to doubt him in the past. Brady’s postseason resume and record alone give value to the Bucs to go all the way.
Further down the odds board, the Jacksonville Jaguars (+4000) enter the playoffs as one of the hottest teams in the league. With a 5-0 winning streak heading into the Wild-Card round, Trevor Lawrence and the Jags are hot at the right time.