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2021 NFL Odds Season D
2021 NFL Odds Season M

2021-2022 NFL Season | Betting Odds, Prop Bets and Futures

2021 NFL Odds & Lines

NFL Odds to Win NFC Conference

151 Tampa Bay Buccaneers +350
152 Green Bay Packers +400
153 Los Angeles Rams +650
154 San Francisco 49ers +650
155 New Orleans Saints +1000
156 Seattle Seahawks +1100
157 Dallas Cowboys +1400
158 Arizona Cardinals +1600
159 Carolina Panthers +2500
160 Atlanta Falcons +2500
161 Minnesota Vikings +2500
162 Washington Football Team +2500
163 Philadelphia Eagles +2500
164 Chicago Bears +2500
165 New York Giants +3000
166 Detroit Lions +6000

NFL Odds to Win AFC Conference

251 Kansas City Chiefs +225
252 Baltimore Ravens +550
253 Buffalo Bills +550
254 Cleveland Browns +900
255 Miami Dolphins +1200
256 Indianapolis Colts +1200
257 New England Patriots +1200
258 Pittsburgh Steelers +1400
259 Tennessee Titans +1600
260 Los Angeles Chargers +1600
261 Las Vegas Raiders +2500
262 Denver Broncos +3300
263 Jacksonville Jaguars +3300
264 New York Jets +4000
265 Cincinnati Bengals +5000
266 Houston Texans +6000

*This NFL Odds may change

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2021 NFL Betting Overview

While the NFL tackled a full season during COVID-19, they are looking to start preparing for the second, but thankfully vaccines will play a major part in whether they can open their stadiums up to bigger crowds and ultimately less risk for players. COVID-19 wreaked havoc on the predictability of the games with players and coaching staff being diagnosed with the virus, and the eerie empty stadiums put a huge damper on the 2020 season.

Did COVID-19 affect the NFL betting odds? Absolutely. It was so difficult for sportsbooks to predict outcomes of games and bettors struggled to stay on top of the ever-changing NFL lines due to the unpredictability of the games themselves.

And now, we are looking to head into a second season while the COVID-19 pandemic rages on. Thankfully with the help of vaccines, this sports betting season should run with some normalcy, and the NFL betting odds will likely be a little more standardized

If you’re new to NFL betting and want to learn more about how the season works, and how you can get in on the action by betting on NFL odds through every phase of the season, read on.

NFL Preseason

Each team will start off their season with three preseason games (since the league added an extra game to regular season, preseason was reduced from four) to get warmed up for the real deal. This is a time for coaches to test rookies or new players in game settings and see how they fit – many rookies or new players are upgraded to the starting line once they perform well during the preseason. The coaches also tend to make cuts after the preseason as well if players are on the bubble.

While betting on the NFL preseason can be trickier due to the unpredictability of the games – due to not having their regular starters playing, sports bettors do bet on the NFL to get some extra practice in.

The 2021 NFL Preseason will begin with the Hall of Fame Game in Canton, Ohio on August 5, 2021 featuring the Dallas Cowboys and the Pittsburgh Steelers.

NFL Regular Season

The 2021 NFL regular season is scheduled to kick off on September 9th, 2021 and run until January 9th, 2022. This will be the 102nd NFL season and will expand from a 16-game season to 17 for all teams. Each team will play the other three teams in their division twice, then one game against four other teams in their conference (intra-conference), and one game against three other teams from the other conference (inter-conference).

This year, a fifth inter-conference game will be added against a team from one of the other three divisions.

Conference pairings for the 2021 season are:


  •   AFC East vs AFC South
  •   AFC North vs AFC West
  •   NFC East vs NFC South
  •   NFC West vs NFC North


  •   AFC East vs NFC South
  •   AFC North vs NFC North
  •   AFC South vs NFC West
  •   AFC West vs NFC East

The reigning champions, the Tampa Bay Buccaneers, will host the NFL Kickoff Game on September 9th, at their home stadium, Raymond James Stadium.

With the addition of an extra game to the regular season schedule, that will make more NFL betting opportunities for sports bettors – lucky us! When betting on the NFL during the regular season, many tend to focus on parlaying wagers on NFL Sundays, and reaping the benefits of having so many games on one single day. This way, you don’t have to wait a few days for the results and find out if you’ve won your bets.

As soon as the regular season schedule is released, NFL odds will pop up all over, and these odds will fluctuate until game day.

NFL Playoffs

Once the regular season concludes, the excitement starts to build as teams are on the road to the Super Bowl – but first, they need to battle it out and win their conference championships. There’s also a wild-card weekend, which allows teams who didn’t make the playoffs on merit vy for a spot in the playoffs.

The NFL playoffs are formatted as a single-elimination style of tournament, where teams will first compete for their conference title, playing teams within their conference in a bracket style, as well as wild card teams. The first-place divisional winner has a bye to the second round, and the second through fourth divisional winners will have to battle the wild card teams in the Wild Card Playoffs.

The divisional playoffs will weed out teams until the AFC and NFC Championship games. Those two conference winners will head to the Super Bowl.

Super Bowl LVI

The 56th Super Bowl will take place in Inglewood California at the SoFi Stadium on February 13, 2022. The Super Bowl is the most popular sporting event in North America, and is the most popular sporting event to bet on around the world. There are countless betting options – you can bet on anything from who will win the game to the length of the national anthem.

Despite losing to the Tampa Bay Buccaneers at Super Bowl LV, the Kansas City Chiefs are favored to win in 2022 at Super Bowl LVI, currently sitting at +500.

You can check out our full Super Bowl betting guide here.

Important NFL Trades/Drafts for 2021

After losing Super Bowl LV to the Buccaneers, Kansas City needed to reevaluate their offensive line – Mahomes got hit and hit hard on quite a few plays, making it their mission in the off-season to pick up a new Offensive Guard. They found one in Joe Thurney, which will greatly improve the Chiefs’ protection of their QB.

When it comes to Quarterback trades, Matthew Stafford was traded to the Los Angeles Rams, to replace Jared Goff, and the Indianapolis Colts picked up Carson Wentz from Philadelphia. At Center, we saw a few movements – Corey Linsley got a hefty contract with the Los Angeles Chargers, protecting Justin Herbert, and the Arizona Cardinals acquired Rodney Hudson from the Raiders.

The New England Patriots made the most power moves in the off season – Belichuck doing what Belichuck does. Signing players who can fill some major roles on the squad.


2021 NFL Kickoff Game on September 9th
Raymond James Stadium

Bet on NFL Odds

How to Bet on NFL Odds: A How-To Guide for Sports Betting

If you’ve found this page, you’re looking to learn how to bet on the NFL. NFL betting is one of the most popular sports to bet on, especially during the Super Bowl and at BetUS Sportsbook, we make it easy to bet on your favorite NFL teams and offer some great bonuses to get you started.

But first, let’s look at the odds and betting types available for NFL betting.

How to Read NFL Betting Odds

It always helps to start new bettors off with introducing them to The Juice. We’re referring to that number in the parenthesis next to your moneyline, point spread or total – it’s the odds of your bet to win.

NFL odds will be displayed next to the team’s name and will be a positive or negative number. This will show you how likely they are to win by that key identifier (+/-). Positive numbers will indicate that the team is less likely to win, and the negative number represents the favored team that is most likely to win out of the two.

If you have the Philadelphia Eagles at +300 and the Washington Football Team at -200, that means that Washington is favored to win that game, and the Eagles are the underdog. A bet on Washington wouldn’t pay out as much because the risk is much smaller. A bet on the Eagles would pay out more because there is much more risk in placing that bet.

The plus and minus number will represent how much you would need to bet to win a certain amount. In the case above, you would need to wager $200 on Washington to win $100 (a total of $300 as you get your initial stake back). You would win $300 on a $100 wager if you decided to take the risk and bet on the Eagles.

A helpful NFL betting tip: when you’re looking at the negative number, that is what you’d have to bet to win $100, and when looking at a positive number, that is what you would win on a $100 bet.

Moneyline NFL Betting

The Moneyline is the most popular way to bet on a variety of popular professional sports, especially when you’re NFL betting though. When betting the moneyline for any NFL Odds, you’re betting on which team will win the game outright. If you want to bet on the New England Patriots to win over the Miami Dolphins, all you have to do is select the Patriots.

Where the odds come in for Moneyline betting, and where it can get a little confusing, is that you might not really make any money if you’re betting the Patriots as a favorite if the line looks something like this:

  • New England Patriots (-350)
  • Miami Dolphins (+500)

You will need to wager $350 to make $100 in profit on the Patriots – is that worth it? Not usually. But if you decided to wager on the Miami Dolphins and they ended up winning, you’d make a pretty penny ($500 plus your $100 bet back) by betting on the underdog.

NFL Point Spreads

NFL point spreads are gaining momentum fast. They are beginning to be one of the top betting types for recreational sports bettors in more recent years but have always been quite popular among the professional sports bettors. This one can be a little more complicated but still relatively easy to understand. In addition to the juice or vig, you’re going to see another number next to each team that usually ranges from 1 to 15 in the NFL respectively.

This number will represent how many points a favored team is expected to win by. So, if we keep in mind that the negative number will represent a favored team, they will be expected to win by that many points. The positive number will give the underdog team that many points as a head start before the game begins. The underdog must lose by less than the point spread number or win the game outright for an underdog point spread to cash.

For example, if the lines look like this:

  • Minnesota Vikings (+3)
  • Green Bay Packers (-3)

In this situation, the Green Bay Packers are the favourite and they’re projected to win the game. If you bet on the Packers, they will have to win by more than three points for your bet to cash. If you bet on the Vikings, who are the underdog in this situation, they will have to win by more than three points OR lose by less than three points. If the final score ended up being a spread of exactly three points, which will be a push and you would get your initial bet back.

NFL Totals

When it comes to NFL betting, there can be instances where you can’t quite risk your betting dollars by picking a team to win. Whether you’re looking at a close or unpredictable game, you can usually rely on the totals to still get your bet in.

Betting the total is also known as the Over/Under, which is exactly how it sounds – you bet whether the total score for both teams will be over the sportsbook’s predicted score, or under. Totals betting is great for beginner bettors, who might not know the teams well enough to place a outright winner or point spread, and can provide great value to parlays if you choose wisely.

If you have a total of 51 on a game between the Minnesota Vikings and Detroit Lions, and you noticed that the Vikings defensive line does very well against pass game, and the Lions heavily rely on their pass game, you might be inclined to take the under as there may not be as many points as expected. If the game’s final score is 28-19, that would be a total of 47, and you would win your bet. If the final score was 34-20, you would lose your bet.

This one is easy to understand and great for first time bettors looking to get their feet wet.

NFL Parlays

A popular NFL betting option that many use to increase the risk and reward of their sports betting strategies include parlay bets.

If you want to up the ante and are feeling good about a few different games, you can combine the odds  for two to 15 single game wagers to make a parlay bet. You can select any NFL betting options, a medley of moneylines, totals, point spreads and even prop bets, and link all their odds together for a much bigger payout than if you bet on all of those games individually. The catch with parlays, is that all of your bets have to cash. If you have a four-game parlay, and only 3 of your bets cash, you lose all of your potential winnings.

NFL Futures

Futures are another easy and fun betting option, where you can bet on the outcome of a certain event or season, months in advance. Usually the day after the Super Bowl, NFL futures odds are released for the following season, with each team’s odds to win the next year’s Super Bowl. There are plenty of futures available on any given day, but there is a surplus of futures wagers around big events or marquee events.

The benefit of betting on futures is that you are betting on one team to win the Super Bowl out of a list of every NFL team. Some are favored, but even the favored teams have pretty substantially high and risky odds – so even a modest wager on these NFL odds will payout extremely well. The only downside is placing your wager and waiting the entire season for the result to pan out.

NFL Prop Bets

Prop bets are gaining popularity year after year and sportsbooks are taking notice and coming up with more and more options – especially here at BetUS. Prop bets usually only occurred around big events like the Super Bowl, but now there are prop bets for almost every preseason, regular season or playoff NFL game, college football game, and you’ll find the same with every professional sport. Prop bets are meant to be fun and you are never able to place huge bets on them, so naturally, there are tons of options available, and you can usually bet on a few different props at once.

A common NFL prop would be predicting the Gatorade color or coin toss at the Super Bowl. They even have crazy half time prop bets you can place as well.

Now that you have a basic understanding of the NFL betting options that are available to you, you can head over to the sportsbook and get started. As soon as the season begins and the NFL odds start popping up, you can expect some great NFL bonuses and promotions. Be sure to sign up for our newsletter to ensure you stay up to date on all the best NFL lines and odds.

Frequently Asked Questions – NFL Odds

How to bet on nfl odds?

Betting on NFL odds isn’t complicated, you will be presented with a number that reflects the team’s odds of winning, and you will have to decide which team will win the game. When it comes to NFL betting odds like totals and point spreads, you will have to assess how many points a team might get in a game, or both teams collectively.

Can I bet on the NFL online?

Yes, you can bet on the NFL online from just about anywhere! You can sign up at the BetUS Sportsbook and bet on NFL odds from your smartphone or computer..

Is Betting on the NFL legal?

Yes, since the legalization of sports betting in the United States, it is perfectly legal to bet on the NFL online, or in person at a brick and mortar sportsbook if you choose. Online sports betting is easy and convenient and allows you access to a wide variety of NFL odds.

How to read nfl odds?

NFL odds can be displayed in a few different formats: American, Fractional, and Decimal. You first will need to understand how to read NFL odds before you bet, and which type is the easiest to understand for you. American odds are the most popular in the United States, and look like (-110), this means you will have to bet that much on a favored team to win $100.

How do nfl odds work?

NFL Odds represent the team’s likelihood of winning a game, or the likelihood of your bet winning. If you are betting on an underdog to win a game, you will likely have some long shot odds, and the less likely they are to win, the odds will increase to a higher number – but, would equal a bigger payout if the bet does win.

Are nfl spreads the same as betting odds?

NFL point spreads have betting odds associated with them to display how much you will win by making that selection. If you are betting on a point spread of -5.5, you would have odds of -110 or something of that nature. This will show you how much you would need to bet to win $100 on that wager, and will show the likelihood of your bet winning.

How to pick betting odds for nfl?

It’s important to do your research into matchups before you bet on the NFL. Keeping an eye on the NFL betting odds will help, as you can see line movement and which side the money is going on. Making your NFL picks should be calculated and factor in all the important metrics like offense vs defense, home/away, and team’s past performances.

Why would you bet on negative odds?

Negative odds represent a favored team. Underdogs don’t win as much as you would want them to, so it’s important when betting on the NFL to pay attention to the negative odds just as much as the positive. Favored teams tend to win more often, and if you are only looking to bet on underdogs, you won’t win very often.

How much money would you win if you bet $100?

It depends on what side of the wager you are betting on. If you bet $100 on +300 underdog NFL odds, you would win $400. If you bet $100 on +1000 odds you would win $1100. Negative odds are the opposite, you would need to bet $110 to win $100. Or for -300, you would need to bet $300 to win $100.

How can I make an NFL Parlay?

NFL parlays are extremely popular each NFL Sunday, and it couldn’t be more simple to do. Choose between two to fifteen bets and combine the odds on your bet slip by creating a parlay. You will need all of these bets to be correct for your bet slip to pay out. Choose the NFL odds that you believe will actually win, and try not to get greedy by picking a bunch of longshots.

Can I use crypto currencies to bet on NFL Games?

Yes, many online sportsbooks accept Cryptocurrencies like Bitcoin, Ethereum, Litecoin, etc for betting on NFL games and sports betting in general. They function like any other currency, and funds can be made available in your account quickly.

Can I bet on NFL games online legally?

Yes, betting on NFL games is legal and a very popular betting option – especially on Super Bowl Sunday. NFL odds are the most bet on sport in the United States, and have been growing exponentially since 2018.

Can I legally bet on NFL games?

Yes, you can legally bet on NFL games during the NFL season. NFL odds will be made available starting in the preseason, and run all the way to Super Bowl Sunday. Once the Super Bowl concludes, you can bet legally on NFL futures to potentially earn some big bucks.

What are some tips to know before betting on NFL games?

Paying attention to team’s records and performances will help you with your betting decisions. Some dynasty teams struggle against certain offensive lines, keep in mind that pass game and run game are defended against differently by each team, and don’t bet on huge favorites.

Why is BetUS a good option to bet NFL Odds online?

BetUS sportsbook has a great selection of NFL odds available during the season, along with a huge selection of prop bets and specials. You can find great NFL odds and betting types, and the sign up process is easy. You can also look forward to seasonal bonuses which include special NFL promotional codes.

Can I Place a Parlay Across Multiple NFL Bets?

Yes, you can bet on multiple NFL games on the same parlay bet slip. You won’t be able to place two wagers on the same game for instance, but you can bet on several different games, even games on different days of the week.

NFL Odds Reviews

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byHugh Clarkman onNFL Odds
KC Coming Back

The chiefs are coming back with a vengeance. Mahomes and company are going to roll through the afc again! Brady’s gonna never make it back. NFL and BetuS. I’m already placing my Super Bowl bets

byTim Bachman onNFL Odds
NFL Draft

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byRichard Brantley onNFL Odds
Getting closer

Step one is over - the nfl draft has been held. Step two is coming soon with the announcement of the schedule, then OTAs and training camps. Then the NFL odds really start to flow. A longer season means more bets and hopefully more wins. You know I’ll be on your site throughout the season for your nfl news and all the bets. NFL and Betus is a great combo

byJanet Roth onNFL Odds
Who will they take?

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Jamie Hudson

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