Man United vs Lyon Prediction, Picks and Odds, April 17: Bet Goals Total Over (-105)
- Over 3 Goals (Ev) is our betting pick between Man United vs. Lyon
- Bruno Fernandes (+160) is one of our best bets for anytime goalscorer.
- Make bank with our Europa League picks! Join with our promo code HUDDLE125.



We look ahead to Thursday’s Europa League clash at Old Trafford with our Man United vs. Lyon soccer predictions and preview.
Manchester United aims to keep their unbeaten record in the Europa League intact as they clash with Lyon at Old Trafford in the second leg of the quarterfinals. Can the Red Devils seal qualification with a win here?
The Red Devils are second favorites to win the competition priced at +350, according to the latest Europa League winner odds.
Man United will continue to assess Matthijs de Ligt, though he is unlikely to be back in time for this game. Amad Diallo and Ayden Heaven are also injured, with Lisandro Martinez out for the rest of the year.
Malick Fofana and Ernest Nuamah are long-term absentees for Lyon. Paul Akouokou had to come off injured in the first leg after a knock and will be assessed, according to Europa League news.
Man United vs Lyon Betting Trends
- Both teams have scored in six of Lyon’s last seven away games.
- Both teams have scored in five of Manchester United’s last six fixtures.
- Manchester United has kept one clean sheet in their last 13 home games, conceding first ten times in that run.
- The Red Devils have won both of their home games against Lyon, and are unbeaten in the five fixtures overall.
- The Premier League side is unbeaten in the Europa League this term, winning six in 11 games.
- The French side won four of their eight group-stage games, with three draws and one defeat.
2 Best Bets for Man United vs Lyon
1. Man United vs Lyon Over 3 Goals (Ev)
Manchester United’s European form at Old Trafford gives them the edge in this encounter. They’ve dominated Lyon in previous home meetings, winning their last three matchups, and their unbeaten run in the Europa League should continue with another statement performance here per Europa League odds.
Both teams have scored in 12 of Lyon’s last 15 competitive games and in six of their last seven away games. They have scored 17 and conceded 11 in these seven trips, per Man United vs Lyon stats.
They have only lost twice in this run, though, and, with Manchester United drawing two of their last three matches, backing an entertaining game with at least three goals looks solid.
Manchester United’s impressive European form at Old Trafford gives them a clear edge in this clash. While their domestic performances have been inconsistent, they’ve looked far more assured on the Europa League stage, so if you love a moneyline bet you should back the hosts.
If you’re looking for a great bet to include in your soccer picks and parlays, back over 3 goals at -105.
Bet This Pick: Over 3 Goals (-105)
2. Best Player Prop Bet: Bruno Fernandes to Score 1+ Goals (+160)
Bruno Fernandes’ last seven UEL goals have come at Old Trafford in Manchester United victories, although four also saw both sides score.
If you’re looking for great soccer player props, back Fernandes to find the back of the net against Lyon.
Bet This Pick: Bruno Fernandes Anytime Goalscorer (+160)
Man United vs Lyon How to Watch
- Match: Man United (6-5-0) vs. Lyon (6-4-1)
- Location: Old Trafford, Manchester, England
- Day/Time: Thursday, April 17, 3 p.m. ET
- Man United vs Lyon Live Stream: FuboTV
Man United enters this clash as slight favorites at -135. You can watch the game on FuboTV on Thursday at 3 p.m. ET.
Question of the Day
Who could score for Lyon against Man United?
An injury-time equalizer from Lyon prodigy Rayan Cherki set this tie on a knife edge last week and the young Frenchman could play a starring role at Old Trafford on Thursday.
He has 11 goals and 17 assists in all competitions and scored for a third successive game at Auxerre on Sunday.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.