Ed's Top 3 NFL Betting Picks - Week 10

Buffalo Bills (6-2) vs. Cleveland Browns (2-6)
Sunday, November 10th - 1:00PM ET - FirstEnergy Stadium, Cleveland, OH
Betting Line: -2.5

It seems the Browns will be the Browns. Another week, another disappointing loss for Cleveland.

This time, Cleveland lost to the Denver Broncos and their backup QB Brandon Allen -- a third-year player that doesn't even have a stat sheet on espn.com.

Despite the question marks surrounding Baker Mayfield, this Browns defense is still supposed to be top notch. That wasn't the case on Sunday against Denver. Brandon Allen passed for 193 yards and two touchdowns in his NFL debut.

They allowed Phillip Lindsay to rush for 92 yards and a score and Noah Fant to catch three passes for 115 yards. Cleveland lost 19-24 to the now 3-6 Broncos.

Buffalo, on the other hand, is playing well. They're 6-2 against mediocre competition, but their play against New England may be the most impressive thing they've done all season.

The Bills have allowed the third fewest passing yards per game 194.4 in the NFL. It will be a long night for Baker Mayfield and the Browns.

Atlanta Falcons (1-7) vs. New Orleans Saints (7-1)
Sunday, November 10th - 1:00PM ET - Mercedes-Benz Superdome, New Orleans, LA
Betting Line: -12.5

Drew Brees is back and he hasn't skipped a beat. The future Hall of Famer returned from injury last week to drop 31 points on the Cardinals. He passed for 373 yards and 3 touchdowns in the process.

Latavius Murray racked up 102 rushing yards and a rushing touchdown plus 55 receiving yards and receiving touchdown in the game. Michael Thomas caught 11 passes for 112 yards and a score of his own.

This Falcons defense will bleed points on Sunday. They've allowed 24 points or more in every loss this season. They're giving up over 31 points per game while averaging almost 21 points of their own.

The scoreboard technician will be busy in this one. Take New Orleans to win by at least a score and if the total is 51 or lower, take the over all the way to the bank.

Seattle Seahawks (7-2) vs. San Francisco 49ers (8-0)
Sunday, November 11th - 8:15PM ET - Levi's Stadium, Santa Clara, CA
Betting Line: -6

The 49ers have dominated opponents all season long with their defense, a defense that has allowed the fewest points in the NFC. That defense will be tested when Russell Wilson and the Seattle Seahawks come to town on Sunday night.

Seattle has played very well against San Fran in recent years. They've won 70% of their games since 2009 and have covered the spread in 75% of those games. But this is a different Niners team.

San Fran began to turn the tide last year when they beat Seattle and covered in their final matchup of the season.

What I'm most interested in is the total. If the oddsmakers put out a total under 45, take it. In 20 games, the total has averaged sub-40. They've averaged under 43 points in their last five games.

I like San Fran to win straight up and hit anything under 45.