Wednesday, August 17
08:46:22 EST


Game 1st H 2nd H 1st Q 2nd Q 3rd Q 4th Q


Sun, Sep 11, 2022 EST

Point Spread
Team Total
-3 -110
53  -110o
+3 -110
53  -110u
Regular Season Week 1.

NFL Chiefs vs Cardinals Week 1


The Chiefs vs Cardinals Week 1 matchup is a battle of young quarterbacks in the NFL. While the Kansas City Chiefs have a Super Bowl MVP quarterback in Patrick Mahomes, the Arizona Cardinals have Kyler Murray. However, the Cardinals have made some moves to help Murray out in the passing department.

During the offseason, the Cardinals traded for the receiver, and former teammate of Murray’s, Hollywood Brown.

They also have DeAndre Hopkins to help Murray. But, for now, Hopkins will serve a six-game suspension which should start during week one.

On the Chiefs’ side, they lost some of their key players during the offseason. They traded Tyreek Hill, their number one receiver. They also let Byron Pringle and Tyrann Mathieu go during free agency.

However, the Chiefs signed Juju Smith-Schuster and Justin Reid to replace Hill and Mathieu. But can Mahomes perform at the highest level without some of his weapons from last season? NFL fans will have to wait until week one to see how he performs without those safety nets he’s had in Kansas City for years.

How do Chiefs vs Cardinals Odds Work for this Matchup?

The Chiefs vs Cardinals matchup, along with the Vegas NFL odds, are something every gambler will examine during this great week one matchup.

NFL point spreads, moneyline wagers, and over/under of total points scored will pique the interest of every gambler.

These betting options and their odds will have a plus or minus sign behind them to represent the return on a wager.

The NFL point spreads give gamblers the choice to take an underdog team while receiving points. If you find a +4.5 point spread, it means losing by four or fewer points gives you a winning wager. Point spreads odds normally run very close to even, with a tiny chance of getting plus odds.

The over/under is a wager on the total points scored in the game by both teams. You could see an over/under of 53.5 points, meaning a wager on the under needs 53 or fewer points to win, while they need 54 points or more to win if they picked the over.

The Vegas NFL odds on moneyline wagers are best suited for the underdog. That means people will use this option if they feel confident their underdog pick can win the game. There is a slight chance for the favorite to have reasonable odds, but only if the game is evenly matched.

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Chiefs vs Cardinals Prop Bets

The NFL Chiefs vs Cardinals week one matchup has something for every gambler with prop bets. With the superstar players on both sides, there’s no lack of variety with player props in this game.

They can also add some added entertainment with a matchup between two teams who have great offensive talent.

Player props for Patrick Mahomes and Kyler Murray and their passing yards or passing touchdowns are popular props to be found with this game.

The number of receiving yards Smith-Schuster and Brown have could be other player props gamblers could find.

There are more props for gamblers to find with this game besides these. However, those are some prop bets most gamblers will wager money on.

Kansas City Chiefs Odds to win the Super Bowl +900

Arizona Cardinals Odds to win the Super Bowl +2800

How to Bet on Chiefs vs Cardinals Matchup

Gamblers are looking for value with the Chiefs vs Cardinals matchup. Both teams have great superstars on their offense, but the Cardinals have some good defensive weapons.

With the Cardinals being early underdogs, the early NFL point spreads for them might tempt gamblers.

The Vegas NFL odds love the Chiefs as three-point road favorites early before the start of the NFL season. If you find this as a three-point game, it might be risky with Mahomes not having all the weapons he’s accustomed to having on offense.

However, without Hopkins playing for the Cardinals, it could help the Chiefs’ defense keep this game close enough for them to cover.

With every NFL game, there’re many options for gamblers to pick. However, most gamblers stick with the ones they feel are the most reliable ones to wager on. Those options are point spreads, over/under, and moneyline wagers.

With NFL point spreads, it’s all about which team can cover those points they would get or give to their opponents. The Chiefs vs Cardinals game could be a runaway if Patrick Mahomes shows flashes of his old self where he’d put up 30 points or more against teams.

However, the Cardinals could pull off an upset if their defense plays well and Murray shows flashes of his early season MVP run from last season.

The Chiefs losing some of their best players concerns those willing to bet on them. They traded Tyreek Hill for draft picks, which they used to get cornerback Trent McDuffie. So getting them early at -3 could be risky when the Chiefs have new players at some key positions.

The Cardinals give gamblers a great option when looking at the next betting option. The moneyline and Vegas NFL odds with a moneyline wager all give the Cardinals plus money.

However, the Cardinals would need their defense to hold Mahomes down and their offense would need to show some life, which it didn’t near the end of last season, to cover that moneyline wager.

A risk on them with the moneyline could pay off if the best players show up for the game. The defense of the Cardinals is key in stopping Mahomes and ruining his chances of an opening week win. However, gamblers might need to wait to see which defensive stars are healthy for this matchup.

The final main wagering option is the over/under. This type of wager requires gamblers to bet on the score, not the teams. While seeing how many points the two teams can score is helpful, it’s not a wager on just one team.

There’s not a lot of data with the two teams facing each other, as this is the first time these two have played each other since 2018. However, gamblers can look at the season totals from both teams during last season against other opponents.

The Vegas NFL odds and the NFL point spreads could easily shift if players are hurt or decide to holdout from playing the game.

That’s why the NFL preseason is important with player injuries and holdouts.Here, you can see which players are ready to go before the Chiefs vs Cardinals week 1 matchup.

Roster moves, along with those injuries and holdouts, can play a role in a team’s chance to win the game. With the Chiefs, they added Justin Reid and Juju Smith-Schuster but lost Tyreek Hill, Byron Pringle, and Tyrann Mathieu.

The Cardinals also made some offseason moves by making a trade deal for Hollywood Brown to help their receiver core. Adding him helps replace Christian Kirk, who left during free agency.

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Chiefs vs Cardinals Matchup Faqs

BetUS and their best Vegas NFL odds available make them a good option when betting online with the Chiefs vs Cardinals matchup.
NFL odds, along with the Chiefs vs Cardinals matchup, can be easily found under the NFL tab of the FOOTBALL section of BetUS. Just click on the odds you like with the best option you want to get your wager placed for the game.
Yes! Any game with Vegas NFL odds has some excellent strategies to use.
Only qualified betting options can be put into a parlay. Those qualified options in your bet slip to the right side of the screen have an option labeled PARLAY. This is the one stop spot for making parlay wagers.
Bet Slip

Your Bet Slip is Empty. To wager with real money...

Fund this wager using a pending wager!

More Details...

Rolling If Bets (RIF) allow you to use the balance (amount) from existing wagers to make a new wager. As long as existing wagers have not been graded, the amount wagered can still be used to make new wagers. However, if your original wager loses, the Rolling If Bet is then cancelled. There are two options for ties (pushes); you can specify if you want the Rolling If Bet to continue in case of a tie or simply cancel the RIF.

Rolling If Bets are:
  • only allowed on straight bets, Parlays and Teasers.
  • not available with Free Plays or Futures and Props
  • only available if you have pre existing, non graded wagers
  • you can only use the funds from the amount of the pre existing wager
How to Place a Rolling If Bet:
  • Choose any straight, parlay or teaser and Place it on the Bet Slip
  • Click on the Rolling If Bet button next to the wager detail
  • In the RIF dropdown, choose a wager that you want to use for RIF
  • Click on "If Win Only" or "If Win or Push" (explained above)
  • Fill in the amount and confirm your wager (the system will not allow you a higher amount than what is available)