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2022 US Open Men’s Odds, Draw Preview and Analysis

Medvedev, Nadal, Alcaraz, Kyrgios Round Out Top 4 Bets

The 2022 US Open men’s betting markets have honed in on four players that have the best chance to win this fourth and final grand slam of the year. Defending champion Daniil Medvedev is the top favorite while 22-time grand slam champion Rafael Nadal comes in as the second choice.

Teenage phenom Carlos Alcaraz and Australia’s No. 1 player Nick Kyrgios are the next best bets on the tennis betting board. After this quartet, the odds jump up significantly with a band of contenders, beginning with Stefanos Tsitsipas, Jannik Sinner, Matteo Berrettini, and Taylor Fritz amongst several others.

Daniil Medvedev of Russia plays a forehand during his match against Stefanos Tsitsipas of Greece during the Western & Southern Open
Daniil Medvedev - Dylan Buell/Getty Images/AFP

Below, we’ll preview the US Open men’s singles draw by looking at each section individually while highlighting the favorites and outside bets to spot from each quarter.

We’ll check the latest Tennis news, stats, injury reports, and Tennis odds for this prestigious fourth and final grand slam and provide some insight into popular Tennis picks and predictions.

2022 US Open Men’s Odds

  • Daniil Medvedev +175
  • Rafael Nadal +350
  • Carlos Alcaraz +400
  • Nick Kyrgios +650
  • Stefanos Tsitsipas +1200
  • Jannik Sinner +1400
  • Felix Auger Aliassime +2000
  • Matteo Berrettini +2000
  • Taylor Fritz +2500
  • Andrey Rublev +2500
  • Borna Coric +2500
  • Dominic Thiem +3000
  • Denis Shapovalov +4000
  • Casper Ruud +4000
  • Cameron Norrie +4000
  • Jenson Brooksby +5000
  • Hubert Hurkacz +5000
  • Andy Murray +5000
  • Marin Cilic +5000
  • Jenson Brooksby +5000
  • Pablo Carreno Busta +6500

First Quarter: Medvedev, Kyrgios, Auger-Aliassime Highlight

Medvedev’s title defense campaign begins against American Stefan Kozlov in the first round. Should Medvedev come through as expected by betting online odds, he could face Quenten Halys or Arthur Rinderknech in the R64.

The third round could be tricky with a possible matchup against American wild card Ben Shelton or dangerous floater Nikoloz Basilashvili. But the fourth round, however, is where things could get tough as a potential matchup against Nick Kyrgios looms. The Aussie recently dispatched Medvedev in three sets in Montreal and he’s been playing some of his best tennis over the last few months.

Felix Auger-Aliassime is the second-highest seed in this section. He could set up a quarterfinal matchup with Medvedev should both get that far in the draw. If Medvedev stumbles early, Kyrgios is the next best bet to emerge from Medvedev’s section into the quarterfinal.

The Canadian’s path to the final eight isn’t straightforward with NextGen star Emil Rusuuvuori looming as R64 challenge. Dangerous floaters such as Alex Molcan, American Denis Kudla and No. 27 seed Karen Kachanov are potential R32 opponents. Whereas Montreal champion Pablo Carreno Busta, Australia’s Alex De Minaur and former US Open champion Domnic Thiem could set up a R16 matchup.

Second Quarter: Tsitsipas, Ruud, Fritz Headline

Greek No.1 Tsitsipas and Norway’s No.1 Casper Ruud are the top two seeds in the second quarter. Both are excellent players but they’re not infallible. This could open the door for Americans Taylor Fritz, Tommy Paul or Maxime Cressy to advance deep into the draw.

Tsitsipas opens his tournament against a qualifier. In the R16, he’ll face the winner of Lorenzo Sonego and Jordan Thompson. The R32 could serve up a tricky matchup with dangerous floater Alejandro Davidovich-Fokina or No. 30 seed Maxime Cressy. Should Tsitsipas get past these early threats, he could see one of several stumbling blocks lining up against him in the R16. These include Matteo Berrettini, Francisco Cerundolo or former US Open champion Andy Murray

Fritz falls into Ruud’s corner of the draw. The American opens his bid against a qualifier. In the R64, he’ll face the winner of Aljaz Bedene and Pedro Cachin. The R32 could have him come up against former US Open champion Stanislas Wawrinka or Botic Van De Zandschulp among several other options.

Things could get tricky in the R16 where a possible all-American clash against Tommy Paul or Sebastian Korda could emerge. However, if the draw falls in line with the seeding, Fritz could face Ruud for a spot in the quarters.

Third Quarter: Alcaraz, Hurkacz, Sinner, Coric Feature

The third quarter of the draw is littered with up-and-comers looking for their big break on the big stage. Third seed Alcaraz leads the charge and he’s joined by No. 8 seed Hubert Hurkacz as the top two seeds in this quarter, whereas Jannik Sinner, seeded 11th, is sandwiched in the middle.

Alcaraz’s path to the quarters could see him face Cincinnati champion Borna Coric in the third round. The resurgent Croatian stunned the tennis betting markets when he upset Nadal on his path to the title. Before the third round, threats include Sebastian Baez and Federico Coria, to name a few.

Should Alcaraz come through the early rounds unscathed, he could face former US Open champion Marin Cilic in the R16 or No. 20 seed, Daniel Evans. Alternative options include James Duckworth, Jiri Vesely, or Albert Ramos-Vinolas, the player that took him to five sets at the French Open.

Hurkacz straddles the top half of this quarter along with Sinner. The pair are on a collision course in the R16 should they persevere through the early rounds. Grigor Dimitrov, Lorenzo Musetti, Americans Brandon Nakashima, Sam Querrey, Steve Johnson, and David Goffin are just some of the many players in this section that could shake things up.

Fourth Quarter: Nadal, Norrie, Rublev, and Tiafoe Highlight

At the face of it, Nadal has a nice draw and what looks to be a straightforward path into the quarterfinals. There are early threats such as dark horse contender Aslan Karatsev and Fabio Fognini in his immediate path, but both players haven’t been in the best of form lately.

In the third round, Nadal could face No. 32 seed Miomir Kecmanovic. In the R16, his opponents could be of several Americans such as Francis Tiafoe, Jack Sock or Marcos Giron. He could also come up against No. 14 seed Diego Schwartzman.

Norrie is adjacent to Nadal in this quarter and if the No.1 Brit plays up to his ranking, he could set up a quarterfinal showdown against the Spaniard.

Before Norrie can look that far ahead, he must navigate several obstacles. Danish teenager and No. 28 seed Holger Rune is a potential R32 threat. However, so is unseeded American John Isner. Should Norrie survive these early tests, he could face Denis Shapovalov or Andrey Rublev in the R16. Alternatively, unseeded threats include Laslo Djere, Soonwoo Kwon, or Jaume Munar.

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