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2022 US Open Quarterfinals: Kyrgios vs Khachanov

Aussie Eyes Second Straight Major Semifinal

Wimbledon runner-up Nick Kyrgios is one win away from reaching his second straight major semifinal and two wins away from the final of a Grand Slam. Standing in his way is Russia’s Karen Khachanov.

BetUS Sportsbook tips Kyrgios as the firm favorite to win this match. He’s also the top favorite to win the US Open title following Rafael Nadal’s untimely upset in the Round of16 to Frances Tiafoe on Monday.

2022 US Open Quarterfinals: Kyrgios vs Khachanov
Mike Stobe/Getty Images/AFP

Kyrgios is the -400 favorite to win while Khachanov is priced at +320. The game handicap is set on a five-game spread while the total is projected to 39 with the over and under on par at -110.

Read on for our Kyrgios vs Khachanov quarterfinal preview at the 2022 US Open.

Let’s check the latest Tennis picks, stats, injury reports, and Tennis odds for Kyrgios vs Khachanov. We’ve plenty of Tennis predictions for you to consider.

US Open Outrights

    • Nick Kyrgios +160
    • Carlos Alcaraz +200
    • Jannik Sinner +550
    • Matteo Berrettini +1100
    • Casper Ruud +1100
    • Frances Tiafoe +1200
    • Andrey Rublev +1400
    • Karen Khachanov +2500

Kyrgios Upset Defending US Open Champion Medvedev

With defending US Open champion Daniil Medvedev and Nick Kyrgios falling into the same quarter of the draw, their possible collision in the R16 was circled as must-see TV for a whole host of reasons — not least of all its upset potential.

The matchup certainly lived up to expectations on all those scores as Kyrgios dismantled Medvedev in four sets, 7-6 (11), 3-6, 6-3, 6-2.

Kyrgios was all business as he secured his fourth win in five meetings with Medvedev. The first set was arguably the best set of tennis from both players. Although Medvedev leveled the match by winning the second set, he never looked to be quite in it.

Much of Medvedev’s success in the second set seemed to be due to Kyrgios taking his foot off the pedal briefly. However, the Aussie bounced back quickly in the third set and ran away with the fourth. He ended the match with 53 winners, 21 of which were aces.

Khachanov in First US Open Quarterfinal

The odds a Russian player would reach the last eight were always high, but Khachanov didn’t factor into that equation. The 26-year-old Russian barely registered on anyone’s radar, priced as the betting online longshot.

And yet, he does now, becoming one of two Russians to rubber-stamp their progress in the men’s draw as the US Open enters the quarterfinal stage.

Khachanov overcame Pablo Carreno-Busta in a five-set marathon on Sunday, 4-6, 6-3, 6-4, 4-6, 6-3. Khachanov served 12 aces and 70% of first serves in the seesaw affair. He won 78% of his first serves and converted on 5 of 15 break-point opportunities.

Kyrgios vs Khachanov Head-to-Head

Kyrgios and Khachanov have split their only two meetings. Khachanov beat Kyrgios in Cincinnati three years ago. Kyrgios returned the favor at the 2020 Australian Open, overcoming the Russian in five sets, 6-2, 7-6 (5), 6-7 (5), 6-7 (7), 7-6 (8).

Kyrgios vs Khachanov Game Information

  • Game: Kyrgios (31-9) vs Khachanov (26-20)
  • Location: Arthur Ashe, Flushing Meadows, Queens, NY
  • Day/Time: Tuesday, Sept. 6, 8 p.m. ET
  • Kyrgios vs Khachanov Live Stream: TennisTV

Kyrgios vs Khachanov Betting Lines

Team Game Hcp Moneyline Total Team Total
Nick Kyrgios -5 -110 -400


Karen Khachanov +5 -110
39-115u 17½-105o


Kyrgios vs Khachanov Prediction

There are no surprises on the tennis odds board. Kyrgios, quite rightly, is the favorite to win. The Aussie has won more matches than any other player on the ATP Tour this summer, capped off with a title in Washington. He’s also very keen to finally win a major title after getting a taste of it at Wimbledon (Kyrgios lost the final to Novak Djokovic.)

Khachanov is an underrated dangerous floater that could shake things up. He’s beaten Kyrgios before, so he’ll fancy his chances against the Australian. Certainly, his chances are better than the odds would suggest.

Then again, this is the first time he’s playing this reinvented, new-look Kyrgios that is playing lights out. You could compare it to facing a new player entirely.

On balance, Kyrgios does have the edge here. He’s also probably a good bet to clinch this match and cover the spread.

Kyrgios has avoided five-set marathons at Flushing Meadows. If he continues to play at this high level, Khachanov will be hard-pressed to push him the distance. Keep in mind, Khachanov is coming off a five-set marathon and he might not have enough left in the tank. Thus, the best bet for the total is under 39.

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