Week 10 features an NFC matchup as the San Francisco 49ers travel to Arlington to face the Dallas Cowboys. NFL odds have the Cowboys as -1½ points home favorites at -1½ (-105), while the 49ers are listed as +1½ (-115) as the road underdog.
The total of 52½ points suggests one of the highest-scoring games on the Week 10 slate. Dallas must win by at least two points to cover the spread, while San Francisco can cover by winning outright or losing by one point. With a narrow spread and a high projected total, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 15, 2026 at 3:25 PM ET
- Spread: Cowboys -1½ (-105) / 49ers +1½ (-115)
- Total: Over 52½ (-110) / Under 52½ (-110)