Monday Night Football on October 5 wraps up NFL Week 4 with the Atlanta Falcons visiting the New Orleans Saints in a key NFC South showdown.
All NFL odds, point spreads, and over/under totals are live at BetUS. Moneylines will be updated in real time as kickoff approaches.
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NFL Week 4’s Monday Night Game
Falcons vs Saints (-1) O/U 48— Monday Night Football closes Week 4 with a classic NFC South rivalry in New Orleans. Division games routinely produce some of the league’s most competitive betting markets, and this primetime matchup should be no exception.
NFL Week 4 Schedule
| Date |
Matchup |
Stadium |
TV Broadcast |
| Thursday, Oct. 1 |
Pittsburgh Steelers vs Cleveland Browns |
Huntington Bank Field |
Prime Video |
| Sunday, Oct. 4 |
Indianapolis Colts vs Washington Commanders |
Tottenham Hotspur Stadium |
NFL Network |
| Sunday, Oct. 4 |
Tennessee Titans vs Baltimore Ravens |
M&T Bank Stadium |
CBS |
| Sunday, Oct. 4 |
New England Patriots vs Buffalo Bills |
Highmark Stadium |
CBS |
| Sunday, Oct. 4 |
New York Jets vs Chicago Bears |
Soldier Field |
FOX |
| Sunday, Oct. 4 |
Jacksonville Jaguars vs Cincinnati Bengals |
Paycor Stadium |
CBS |
| Sunday, Oct. 4 |
Dallas Cowboys vs Houston Texans |
NRG Stadium |
FOX |
| Sunday, Oct. 4 |
Arizona Cardinals vs New York Giants |
MetLife Stadium |
CBS |
| Sunday, Oct. 4 |
Los Angeles Rams vs Philadelphia Eagles |
Lincoln Financial Field |
FOX |
| Sunday, Oct. 4 |
Green Bay Packers vs Tampa Bay Buccaneers |
Raymond James Stadium |
FOX |
| Sunday, Oct. 4 |
Miami Dolphins vs Minnesota Vikings |
U.S. Bank Stadium |
FOX |
| Sunday, Oct. 4 |
Kansas City Chiefs vs Las Vegas Raiders |
Allegiant Stadium |
CBS |
| Sunday, Oct. 4 |
Los Angeles Chargers vs Seattle Seahawks |
Lumen Field |
CBS |
| Sunday, Oct. 4 |
Denver Broncos vs San Francisco 49ers |
Levi’s Stadium |
CBS |
| Sunday, Oct. 4 |
Detroit Lions vs Carolina Panthers |
Bank of America Stadium |
NBC |
| Monday, Oct. 5 |
Atlanta Falcons vs New Orleans Saints |
Caesars Superdome |
ESPN |
What are the favorite types of bets for NFL Week 4?
NFL Week 4 odds cover all the core bet types available at BetUS. Here’s how each one works:
NFL Point Spread: The spread is the most popular way to bet on NFL Week 4 games. The favorite is listed with a minus sign, while the underdog carries a plus sign. For example, the Indianapolis Colts are -3 against the Washington Commanders in London’s international matchup — landing on three, the NFL’s most common winning margin, so a Colts win by exactly three now pushes. Washington covers by winning outright or losing by two or fewer; Indianapolis needs four or more to cover outright. Point spreads are available on every NFL Week 4 matchup at BetUS.
NFL Moneyline: The moneyline lets you wager on which team wins outright regardless of the margin. Favorites carry minus odds while underdogs offer plus-money payouts. BetUS updates NFL Week 4 moneylines continuously leading up to kickoff.
NFL Totals (Over/Under): The total represents the combined points expected in each game. Colts vs Commanders now sits at 47, up from 45½ — a whole number, so a combined 47 points pushes the bet rather than settling it either way. Patriots vs Bills sits among the week’s higher totals at 48½, though Jaguars vs Bengals currently tops the board at 51½. Totals are available for every NFL Week 4 game at BetUS.
What key factors influence NFL Week 4 odds?
NFL Week 4 odds are shaped by three weeks of regular-season action, allowing sportsbooks to make more refined adjustments based on team performance, injuries, quarterback play, and betting market trends. By this stage of the season, power ratings begin to stabilize as contenders emerge and underperforming teams look to rebound.
Additional factors influencing NFL Week 4 betting lines include injury reports, travel schedules, home-field advantage, divisional familiarity, weather forecasts, and line movement throughout the week. The Colts vs. Commanders game in London also adds unique travel and neutral-site considerations that bettors should weigh before placing wagers.
NFL Odds Week 5 will continue to evolve based on Week 4 performances as sportsbooks react to injuries, breakout teams, and changing betting trends.
Why Choose BetUS for NFL Week 4 Betting?
BetUS delivers a complete NFL Week 4 betting experience with updated spreads, moneylines, totals, player props, team totals, same-game parlays, and live betting markets for every matchup.
Our mobile-friendly sportsbook allows you to track line movement throughout the week and place wagers wherever you are. Odds are updated continuously to reflect injuries, weather reports, betting action, and the latest market information, ensuring you always have access to the most current NFL Week 4 lines.
For bettors looking beyond the weekly slate, explore our full selection of NFL Futures alongside every NFL Week 4 betting market available at BetUS.
