Week 4 of the 2026 NFL odds season begins with the league’s first international game of the year as the Indianapolis Colts face the Washington Commanders at Tottenham Hotspur Stadium in London. Washington enters as a 1½-point favorite with the total set at 48½.
The Sunday card on October 4 features a full slate of conference showdowns and divisional rivalries, highlighted by Chiefs vs Raiders in an AFC West battle, Packers vs Buccaneers, Dolphins vs Vikings, and Sunday Night Football between the Detroit Lions and Carolina Panthers.
Monday Night Football on October 5 wraps up NFL Week 4 with the Atlanta Falcons visiting the New Orleans Saints in a key NFC South showdown.
All NFL Week 4 point spreads and over/under totals are live at BetUS. Moneylines will be posted and updated in real time as kickoff approaches.
Key Matchups & Betting Angles
?? Colts (+1½) vs Commanders (-1½) O/U 48½ — NFL Week 4 kicks off from London as the Colts and Commanders meet at Tottenham Hotspur Stadium. Washington enters as a slight favorite in one of the week’s most intriguing neutral-site matchups.
?? Chiefs (-5½) vs Raiders (+5½) O/U 43½ — AFC West rivals meet in Las Vegas with Kansas City looking to strengthen its position inside the division. Divisional games are often among the toughest contests on the betting board.
?? Jaguars (+2½) vs Bengals (-2½) O/U 51½ — Cincinnati hosts Jacksonville in the highest-total game on the Week 4 board. With a projected 51½ points, this matchup shapes up as one of the week’s premier over/under opportunities.
?? Packers (-1½) vs Buccaneers (+1½) O/U 47½ — Green Bay travels to Tampa Bay in one of the closest games of the week. With the spread sitting at just 1½ points, bettors can expect a highly competitive NFC matchup.
?? Falcons vs Saints — Monday Night Football closes Week 4 with a classic NFC South rivalry in New Orleans. Division games routinely produce some of the league’s most competitive betting markets and this primetime matchup should be no exception.
NFL Week 4 Schedule
| Date |
Matchup |
Stadium |
TV Broadcast |
| Sunday, Oct. 4 |
Indianapolis Colts vs Washington Commanders |
Tottenham Hotspur Stadium (London, England) |
NFL Network |
| Sunday, Oct. 4 |
Arizona Cardinals vs Seattle Seahawks |
Lumen Field |
FOX |
| Sunday, Oct. 4 |
Buffalo Bills vs New England Patriots |
Gillette Stadium |
CBS |
| Sunday, Oct. 4 |
Carolina Panthers vs Detroit Lions |
Ford Field |
NBC / Peacock |
| Sunday, Oct. 4 |
Cleveland Browns vs Cincinnati Bengals |
Paycor Stadium |
CBS |
| Sunday, Oct. 4 |
Houston Texans vs Tennessee Titans |
Nissan Stadium |
CBS |
| Sunday, Oct. 4 |
Jacksonville Jaguars vs Cincinnati Bengals |
Paycor Stadium |
CBS |
| Sunday, Oct. 4 |
Kansas City Chiefs vs Las Vegas Raiders |
Allegiant Stadium |
CBS |
| Sunday, Oct. 4 |
Miami Dolphins vs Minnesota Vikings |
U.S. Bank Stadium |
FOX |
| Sunday, Oct. 4 |
New York Giants vs Los Angeles Chargers |
SoFi Stadium |
FOX |
| Sunday, Oct. 4 |
New York Jets vs Baltimore Ravens |
M&T Bank Stadium |
CBS |
| Sunday, Oct. 4 |
Philadelphia Eagles vs Tampa Bay Buccaneers |
Raymond James Stadium |
FOX |
| Sunday, Oct. 4 |
Pittsburgh Steelers vs Green Bay Packers |
Lambeau Field |
CBS |
| Sunday, Oct. 4 |
San Francisco 49ers vs Los Angeles Rams |
SoFi Stadium |
FOX |
| Sunday, Oct. 4 |
Detroit Lions vs Carolina Panthers |
Bank of America Stadium |
NBC / Peacock |
| Monday, Oct. 5 |
Atlanta Falcons vs New Orleans Saints |
Caesars Superdome |
ESPN / ABC |
What are the favorite types of bets for NFL Week 4?
NFL Week 4 odds cover all the core bet types available at BetUS. Here’s how each one works:
NFL Point Spread: The spread is the most popular way to bet on NFL Week 4 games. The favorite is listed with a minus sign, while the underdog carries a plus sign. For example, the Washington Commanders are -1½ against the Indianapolis Colts in London’s international matchup. Washington must win by two or more points to cover, while Indianapolis cashes at +1½ by winning outright or losing by one. Point spreads are available on every NFL Week 4 matchup at BetUS.
NFL Moneyline: The moneyline lets you wager on which team wins outright regardless of the margin. Favorites carry minus odds while underdogs offer plus-money payouts. NFL Week 4 moneylines are updated continuously at BetUS leading up to kickoff.
NFL Totals (Over/Under): The total represents the combined points expected in each game. Jaguars vs Bengals leads the Week 4 slate with a total of 51½, making it one of the week’s top over/under betting opportunities. Totals are available for every NFL Week 4 game at BetUS.
What key factors influence NFL Week 4 odds?
NFL Week 4 odds are shaped by three weeks of regular-season action, allowing sportsbooks to make more refined adjustments based on team performance, injuries, quarterback play, and betting market trends. By this stage of the season, power ratings begin to stabilize as contenders emerge and underperforming teams look to rebound.
Additional factors influencing NFL Week 4 betting lines include injury reports, travel schedules, home-field advantage, divisional familiarity, weather forecasts, and line movement throughout the week. The Colts vs Commanders game in London also introduces unique travel and neutral-site considerations that bettors should evaluate before placing wagers.
NFL Odds Week 5 will continue to evolve based on Week 4 performances as sportsbooks react to injuries, breakout teams, and changing betting trends.
Why Choose BetUS for NFL Week 4 Betting?
BetUS delivers a complete NFL Week 4 betting experience with updated spreads, moneylines, totals, player props, team totals, same-game parlays, and live betting markets for every matchup.
Our mobile-friendly sportsbook allows you to track line movement throughout the week and place wagers wherever you are. Odds are updated continuously to reflect injuries, weather reports, betting action, and the latest market information, ensuring you always have access to the most current NFL Week 4 lines.
For bettors looking beyond the weekly slate, explore our full selection of NFL Futures alongside every NFL Week 4 betting market available at BetUS.
