Week 5 of the 2026 NFL odds season begins with Thursday Night Football as the Tampa Bay Buccaneers travel to AT&T Stadium to face the Dallas Cowboys. Dallas opens as a 9-point favorite with the total set at 47½.
The Sunday card on October 11 features another international showcase as the Philadelphia Eagles meet the Jacksonville Jaguars in London, along with several marquee conference matchups, including Bears vs Packers, 49ers vs Seahawks, and Sunday Night Football between the Baltimore Ravens and Atlanta Falcons.
Monday Night Football on October 12 wraps up NFL Week 5 with the Buffalo Bills visiting the Los Angeles Rams in a matchup between two Super Bowl contenders.
All NFL Week 5 moneylines, point spreads, and over/under totals are live at BetUS.
Key Matchups & Betting Angles
Buccaneers vs Cowboys (-9) O/U 47½ — Thursday Night Football opens Week 5 with Dallas now a heavy home favorite. The total has come down significantly from where it opened, pointing to a more one-sided, lower-scoring affair than the market expected earlier in the week — Tampa Bay will need a genuine road upset, not just a competitive showing, to cover.
Eagles vs Jaguars (-7½) O/U 42 — The NFL returns to London as Philadelphia and Jacksonville square off in an international matchup featuring two teams with playoff aspirations. Neutral-site games often offer unique betting angles because of travel and preparation.
Bears (-3) vs Packers O/U 45½ — One of the NFL’s oldest rivalries returns to Lambeau Field. Regardless of records, these NFC North clashes are typically among the most competitive games on the weekly betting board.
49ers vs Seahawks (-3) O/U 46½ — NFC West rivals meet in Seattle in a game with potential playoff implications. Divisional familiarity and home-field advantage make this one of Week 5’s featured betting matchups.
Ravens vs Falcons (-3½) O/U 44 — Sunday Night Football showcases two explosive offenses in Atlanta, with the total still among the week’s higher numbers even as Baltimore’s line has widened. With playoff-caliber talent on both sidelines, this primetime matchup is expected to attract significant betting action.
NFL Week 5 Schedule
| Date |
Matchup |
Stadium |
TV Broadcast |
| Thursday, Oct. 8 |
Tampa Bay Buccaneers vs Dallas Cowboys |
AT&T Stadium |
Prime Video |
| Sunday, Oct. 11 |
Philadelphia Eagles vs Jacksonville Jaguars |
Tottenham Hotspur Stadium |
NFL Network |
| Sunday, Oct. 11 |
Houston Texans vs Tennessee Titans |
Nissan Stadium |
CBS |
| Sunday, Oct. 11 |
Minnesota Vikings at New Orleans Saints |
Caesars Superdome |
FOX |
| Sunday, Oct. 11 |
Cleveland Browns at New York Jets |
MetLife Stadium |
CBS |
| Sunday, Oct. 11 |
Cincinnati Bengals at Miami Dolphins |
Hard Rock Stadium |
FOX |
| Sunday, Oct. 11 |
Las Vegas Raiders at New England Patriots |
Gillette Stadium |
CBS |
| Sunday, Oct. 11 |
Indianapolis Colts at Pittsburgh Steelers |
Acrisure Stadium |
CBS |
| Sunday, Oct. 11 |
New York Giants at Washington Commanders |
Northwest Stadium |
FOX |
| Sunday, Oct. 11 |
Denver Broncos at Los Angeles Chargers |
SoFi Stadium |
CBS |
| Sunday, Oct. 11 |
Detroit Lions at Arizona Cardinals |
State Farm Stadium |
FOX |
| Sunday, Oct. 11 |
Chicago Bears at Green Bay Packers |
Lambeau Field |
FOX |
| Sunday, Oct. 11 |
San Francisco 49ers at Seattle Seahawks |
Lumen Field |
FOX |
| Sunday, Oct. 11 |
Baltimore Ravens at Atlanta Falcons |
Mercedes-Benz Stadium |
NBC / Peacock |
| Monday, Oct. 12 |
Buffalo Bills at Los Angeles Rams |
SoFi Stadium |
ESPN / ABC |
What are the favorite types of bets for NFL Week 5?
NFL Week 5 odds cover all the core bet types available at BetUS. Here’s how each one works:
NFL Point Spread: The spread is the most popular way to bet on NFL Week 5 games. The favorite is listed with a minus sign, while the underdog carries a plus sign. For example, the Dallas Cowboys are -9½ against the Tampa Bay Buccaneers on Thursday Night Football. Dallas must win by 10 or more points to cover, while Tampa Bay cashes at +9½ by winning outright or losing by 9 or fewer. Point spreads are available on every NFL Week 5 matchup at BetUS.
NFL Moneyline: The moneyline lets you wager on which team wins outright regardless of the margin. Favorites carry minus odds while underdogs offer plus-money payouts. NFL Week 5 moneylines are updated continuously at BetUS leading up to kickoff.
NFL Totals (Over/Under): The total represents the combined points expected in each game. Buccaneers vs Cowboys sits among the week’s higher totals at 52½, making it one of the week’s top over/under betting opportunities. Totals are available for every NFL Week 5 game at BetUS.
What key factors influence NFL Week 5 odds?
NFL Week 5 odds are influenced by a full month of regular-season action, giving sportsbooks a clearer picture of each team’s strengths, weaknesses, and overall power rating. Injuries, quarterback play, coaching adjustments, and early-season trends all play a larger role in shaping betting lines.
Additional factors influencing NFL Week 5 betting lines include injury reports, travel schedules, home-field advantage, divisional familiarity, weather forecasts, and line movement throughout the week. The Eagles vs Jaguars game in London also introduces unique travel and neutral-site considerations that bettors should evaluate before placing wagers.
NFL Odds Week 6 will continue to evolve based on Week 5 performances as sportsbooks adjust power ratings, react to injuries, and account for emerging contenders and shifting betting trends.
Why Choose BetUS for NFL Week 5 Betting?
BetUS delivers a complete NFL Week 5 betting experience with updated spreads, moneylines, totals, player props, team totals, same-game parlays, and live betting markets for every matchup.
Our mobile-friendly sportsbook allows you to track line movement throughout the week and place wagers wherever you are. Odds are updated continuously to reflect injuries, weather reports, betting action, and the latest market information, ensuring you always have access to the most current NFL Week 5 lines.
For bettors looking beyond the weekly slate, explore our full selection of NFL Futures alongside every NFL Week 5 betting market available at BetUS.
