Buffalo travels to SoFi Stadium for Monday Night Football in a rare interconference meeting and a rematch of one of the highest-scoring games in recent NFL history. Check the latest NFL odds as you follow along. The Bills lead the all-time series 9-6, but the Rams won the last meeting 44-42 in December 2024, the first time they had beaten Buffalo since 2012 and their first home win in the series since 1983.
That game produced 86 combined points, the most in any NFL game that season, and neither team committed a turnover. Josh Allen scored all six Buffalo touchdowns, throwing for three and running for three, the first player in NFL history to do both. Matthew Stafford passed for 320 yards, and Puka Nacua caught 12 passes for 162 yards, including the go-ahead touchdown with 1:54 remaining. The loss snapped a seven-game Bills winning streak and was the first time Buffalo had lost a game in which it scored 40 points.
Bills at Rams Match Details
- Game: Monday, October 12, 2026
- Kickoff: 8:15 PM ET
- Venue: SoFi Stadium, Inglewood, CA
- Broadcast: ESPN/ABC (Monday Night Football)
- Storyline: The Bills lead the all-time series 9-6, but the Rams won the last meeting 44-42 in December 2024, a game with 86 combined points, no turnovers, and a six-touchdown performance from Josh Allen.
Spread Analysis
The last meeting was decided in the final two minutes, and before that the Bills had won by 21 points in the 2022 season opener, so this series has produced both a blowout and a one-score finish recently. Both teams’ quarterbacks played a central role in the 2024 result, and each defense will be looking to avoid a repeat of the 902 combined yards of offense.
Total Betting Trends
The last two meetings produced 41 and 86 combined points, a wide range. For anyone following the over/under conversation, the 2024 game is the clearest example of what these two offenses can do when neither commits a turnover, but this year’s matchup depends more on current-season form than on any single result.
