Week 11 features an AFC East divisional matchup as the Miami Dolphins travel to Orchard Park to face the Buffalo Bills. NFL odds have the Bills as -11½ points home favorites at -11½ (-110), while the Dolphins are listed as +11½ (-110) as the road underdog.
The total of 47½ points suggests plenty of scoring opportunities despite Buffalo entering as a sizable favorite. The Bills must win by at least 12 points to cover the spread, while Miami can cover by winning outright or losing by 11 points or fewer. With a double-digit spread and division bragging rights on the line, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 22, 2026 at 12:00 PM ET
- Spread: Bills -11½ (-110) / Dolphins +11½ (-110)
- Total: Over 47½ (-110) / Under 47½ (-110)