NFL Week 1 Odds and Betting Lines 2026

The 2026 NFL odds for Week 1 open with one of the most compelling slates in recent memory. Action begins on Wednesday, September 9, with the New England Patriots visiting the Seattle Seahawks, before the 49ers and Rams make history with the league’s first-ever regular-season game played in Australia at the Melbourne Cricket Ground on Thursday, September 10.

The full Sunday card on September 13 delivers wall-to-wall action across all three bet types — spreads, moneylines, and totals — with marquee matchups including Bills vs Texans, Eagles vs Commanders, Lions vs Saints, and the Cowboys vs Giants Sunday Night Football showdown. Monday Night Football on September 14 closes the week with Broncos vs Chiefs at Arrowhead Stadium — one of the most anticipated season-opening matchups on the board.

All 16 NFL Week 1 point spreads and totals are live, with moneylines posted on most games at BetUS

NFL Week 1 Point Spreads & Odds — Key Matchups

New England Patriots vs Seattle Seahawks — Season Opener

Wednesday, September 9 · 8:20 PM EST · Lumen Field · NBC/Peacock

The 2026 season opens on a Wednesday night in Seattle, with the Seahawks favoured by 3½ and the total at 44. Seattle is -180 on the moneyline, New England +155.
The 3½ sits just above the key number of 3, so New England covers on a three-point loss — the single most likely outcome for a road underdog getting less than a touchdown. The pricing agrees: the Patriots at -115 are the more expensive side against the Seahawks at -105, which suggests the market’s true number is nearer 3 and the line may drift down. Note also that the total is a whole number — a 44-point game pushes.

San Francisco 49ers vs Los Angeles Rams Odds — NFL Australia Game

Thursday, September 10 · 8:35 PM EST · Melbourne Cricket Ground · Netflix

The Rams are the designated home team for the league’s first regular-season game in Australia, but the designation is nominal — no crowd advantage, and both teams travelled the same 7,500 miles. That changes how the number reads. Home field is normally worth two to three points, so a -4 at a neutral site means the market rates Los Angeles four points better on merit, not simply at home.

Both main numbers are whole: a Rams win by exactly four pushes, and a 48-point game pushes too. The 4 also sits in the dead zone between 3 and 7. As with the opener, the underdog is the pricier side (-115 against -105), pointing to a true number closer to 3½.

Tampa Bay Buccaneers vs Cincinnati Bengals

Sunday, September 13 · 1:00 PM EST · Paycor Stadium · FOX

The total is the headline: 50½, the highest on the Week 1 board and eleven points above the lowest (Jets at Titans, 39½). Cincinnati is a 4-point home favourite at -210, with Tampa Bay at +180.

The totals pricing carries a lean the spread doesn’t: the under is -115 against -105 on the over, so money is arriving on the lower side of an already-high number. On the spread, both sides are -110 with no signal, and the 4 offers no key-number protection.

Buffalo Bills vs Houston Texans Odds — Week 1

Sunday, September 13 · 1:00 PM EST · NRG Stadium · CBS

A true pick’em, -110 on both sides — the tightest game on the board, and more interesting than it looks because it’s in Houston. Home field is generally worth two to three points, so a pick’em at NRG means the market rates Buffalo as the better team by roughly the value of home field, with the venue cancelling it out.

Two practical notes. There is no moneyline posted on this game, so the spread is the only way to back a side. And at pick’em, a tie pushes — rare, but the only outcome that returns your stake rather than settling.

New Orleans Saints vs Detroit Lions Odds — Week 1

Sunday, September 13 · 1:00 PM EST · Ford Field · FOX

Detroit is the largest home favourite of the early Sunday window at -7, with the total at 50 — second-highest on the board. Together they imply roughly 28-21.

Both numbers are whole, and both are common outcomes. Seven is the second-most frequent NFL margin after three, so a Lions win by exactly seven refunds the spread. Fifty is likewise a live combined total. That’s unusual double push exposure in one game. Bettors who want to avoid it have clean alternatives: Saints +253 needs an outright upset but carries no push risk, and Lions -305 pays on any win.

Kansas City Chiefs vs Denver Broncos Odds — Monday Night Football

Monday, September 14 · 8:15 PM EST · GEHA Field at Arrowhead Stadium · ESPN/ABC

Patrick Mahomes and the Kansas City Chiefs open Monday Night Football as 3-point favorites over the Denver Broncos at Arrowhead Stadium, with the total set at 42½. The Chiefs are installed at -140 on the moneyline, with Denver available at +120 — a competitive price that reflects what promises to be a tight AFC West rivalry opener. The total of 42½ is one of the lower marks on the Week 1 board, pointing toward a defensively grounded contest between two teams that know each other well. Bettors looking at the Chiefs spread will note the -105 juice on the Kansas City side, making it one of the better-priced favorites of the opening week.

Dallas Cowboys vs New York Giants Odds — Sunday Night Football

Sunday, September 13 · 8:20 PM EST · MetLife Stadium · NBC/Peacock

Two whole numbers again, and consequently so. Dallas is -3, exactly on the most common NFL margin, so a three-point Cowboys win pushes rather than covers. The total of 48 is likewise flat, with a 48-point game refunding both sides.

Both spread prices are -110, so the market has no directional view — it reads this as a genuine three-point game. The total does lean, with the over at -115 against -105 on the under. For push-averse bettors, Dallas -160 on the moneyline pays on any win, and the Giants at +138 need only a one-point upset.

Denver Broncos vs Kansas City Chiefs — Monday Night Football

Monday, September 14 · 8:15 PM EST · GEHA Field at Arrowhead Stadium · ESPN/ABC

Kansas City closes Week 1 as a 2-point home favourite, down from 3, with the total at 43½. The Chiefs are -140 on the moneyline, Denver +120.

The move below 3 is the whole story. At -2, a three-point Kansas City win — the likeliest single margin in football — covers for Denver. That’s a materially different bet from -3, where it would have pushed. The pricing confirms the market thinks the number belongs higher: Chiefs -2 costs -120 while Broncos +2 is available at even money, so the book is charging a premium for the favourite. Anyone taking Denver is getting both the hook and the better price; anyone taking Kansas City should watch for a move back to -2½ or -3. The 43½ total is among the lowest of the week.

What are the favorite types of bets for NFL Week 1?

NFL odds come in a few main categories:

• NFL Spread: One team is the favorite, marked with a minus sign and a number next to its points; the other is the underdog, marked with a plus sign. In the Week 1 opener, for example, the Chargers are -10½ against the Cardinals, meaning Los Angeles must win by 11 or more to cover, while Arizona at +10½ covers by winning outright or losing by 10 or fewer.
• NFL Moneyline: This market uses plus and minus signs to price a straight-up winner. A favorite is listed as a minus number — the Bills at -115 means you’d bet $115 to win $100. An underdog is a plus number — the Texans at -105 in that same game are nearly a coin flip, while a bigger underdog like the Cardinals at +450 means a $100 bet would return $450 if they win.
• NFL Totals (over/under): This is a line set for the combined points both teams are expected to score. In the Bengals-Buccaneers game, the total is 52 — the highest on the Week 1 Sunday slate. Bettors wager on whether the final combined score lands over 52 or under it, regardless of who wins.

What key factors influence the setting of NFL Week 1 odds?

NFL odds Week 1 are influenced by what teams did in the previous season and offseason. While the prior campaign doesn’t always dictate success or failure in the next one, it does provide a barometer for how a team has done.

Add in other factors like coaching changes, free-agent signings, trades, and draft picks, and BetUS and all other sportsbooks have a gauge to make a line. Throw in where the game is played, who is home, and who is away, and the thought process can be completed. NFL Week 1 Odds & Betting Lines are a great chance to find the spot to make plays before the season takes its shape.

NFL Odds Week 2 are determined in a big way by what happens in Week 1. Who wins, who loses, what players thrive, and which ones nosedive.

Additionally, home-field advantage influences the decision on where to set the ATS and moneyline. And depending on how many points were scored by teams in Week 1 games, that could impact the totals for Week 2.

What are other types of bets for NFL Week 1?

As mentioned, common types of bets for NFL Week 1 are ATS, Moneyline, and Totals. There are also numerous options in the prop market, and one can tie wagers together on the same game or different ones by making plays.

An aside to NFL Week 1 bets, are futures. They can be found on BetUS and provide opportunities to bet on teams one thinks will win the Super Bowl.

To cash an NFL Super Bowl odds bet, the team you bet on has to win the NFL championship game. The futures markets fluctuate depending on what happens in the offseason and are adjusted week-to-week based on news and game results.

Why Choose BetUS for NFL Betting

Our user-friendly NFL betting platform makes it a breeze to navigate through all the NFL Week 1 odds. Whether you’re looking to place a spread bet, back your favorite team on the moneyline, or wager on the game total, you’ll find all these options and more just a few clicks away. For those seeking even more excitement, explore our wide range of game props that let you bet on specific player performances, team statistics, and game events.

We pride ourselves on offering up-to-the-minute NFL Week 1 odds that reflect the latest NFL news, injury reports, and team developments. This ensures that you always have access to the most current lines when you’re ready to place your bets. Our mobile-optimized site allows you to check odds and make wagers on the go, so you never miss out on a great betting opportunity.