NFL Week 1 Odds and Betting Lines 2026

The 2026 NFL odds for Week 1 open with one of the most compelling slates in recent memory. Action begins on Wednesday, September 9 with the New England Patriots visiting the Seattle Seahawks, before the 49ers and Rams make history with the league’s first-ever regular season game played in Australia at the Melbourne Cricket Ground on Thursday, September 10.

The full Sunday card on September 13 delivers wall-to-wall action across all three bet types — spreads, moneylines, and totals — with marquee matchups including Bills vs Texans, Eagles vs Commanders, Lions vs Saints, and the Cowboys vs Giants Sunday Night Football showdown. Monday Night Football on September 14 closes the week with Broncos vs Chiefs at Arrowhead Stadium — one of the most anticipated season-opening matchups on the board.

All 16 NFL Week 1 point spreads, moneylines, and over/under totals are live and updated in real time at BetUS.

NFL Week 1 Point Spreads & Odds — Key Matchups

Kansas City Chiefs vs Denver Broncos Odds — Monday Night Football

Monday, September 14 · 8:15 PM EST · GEHA Field at Arrowhead Stadium · ESPN/ABC

Patrick Mahomes and the Kansas City Chiefs open Monday Night Football as 3-point favorites over the Denver Broncos at Arrowhead Stadium, with the total set at 42½. The Chiefs are installed at -140 on the moneyline, with Denver available at +120 — a competitive price that reflects what promises to be a tight AFC West rivalry opener. The total of 42½ is one of the lower marks on the Week 1 board, pointing toward a defensively grounded contest between two teams that know each other well. Bettors looking at the Chiefs spread will note the -105 juice on the Kansas City side, making it one of the better-priced favorites of the opening week.

Buffalo Bills vs Houston Texans Odds — Week 1

Sunday, September 13 · 1:00 PM EST · NRG Stadium · CBS

One of the tightest Week 1 lines on the board — the Buffalo Bills are just 1-point favorites over the Houston Texans, with the moneyline set at Bills -115 and Texans -105. This near-even split signals oddsmakers view this as a genuine toss-up between two AFC playoff contenders. The 44½ total is moderate for a Bills matchup, suggesting a competitive defensive effort from both sides. With home-field advantage and a crowd at NRG Stadium, Houston represents legitimate value for bettors eyeing the underdog or the plus side of the spread.

Washington Commanders vs Philadelphia Eagles Odds — Week 1

Sunday, September 13 · 4:25 PM EST · Lincoln Financial Field · FOX

The defending NFC East champions open at home as 4-point favorites, with the Eagles moneyline priced at -210 and Washington at +180. This is one of the larger spreads on the Sunday afternoon slate and reflects Philadelphia’s status as one of the conference’s top teams heading into the 2026 season. The 47½ total is among the higher marks of the early window, suggesting a higher-scoring divisional affair. Bettors on the Commanders +4 get the benefit of plus-money juice at -105 — among the more appealing underdog spread prices of the week.

Dallas Cowboys vs New York Giants Odds — Sunday Night Football

Sunday, September 13 · 8:20 PM EST · MetLife Stadium · NBC/Peacock

Sunday Night Football kicks off with one of the NFL’s most storied NFC East rivalries — the Dallas Cowboys at the New York Giants, with Dallas installed as 3-point road favorites at -150 on the moneyline. The Giants are priced at +129, making them one of the more accessible underdogs of the primetime slate. The 48-point total is the highest of the Sunday evening matchups, indicating expectations of an open, high-tempo offensive game. Cowboys -3 at standard -110 juice is a straightforward line; bettors looking for value may find it on the Giants side given the home-field edge at MetLife.

New Orleans Saints vs Detroit Lions Odds — Week 1

Sunday, September 13 · 1:00 PM EST · Ford Field · FOX

Detroit opens as one of the biggest home favorites of Week 1 at -7 against the New Orleans Saints, with the Lions moneyline at -335 and the Saints at a generous +272. The 50-point total is the joint-highest on the Sunday slate, reflecting confidence in Detroit’s high-octane offense and expectations of a fast-paced game at Ford Field. For bettors looking at the Saints, the +7 at standard juice gives seven points of cushion in what oddsmakers project as a comfortable Lions win — though New Orleans at +272 on the moneyline is among the more tempting underdog prices of the early afternoon window.

San Francisco 49ers vs Los Angeles Rams Odds — NFL Australia Game

Thursday, September 10 · 8:35 PM EST · Melbourne Cricket Ground · Netflix

The most unique game of NFL Week 1 takes place in Melbourne, Australia — the first-ever NFL regular season game played on Australian soil — as the Los Angeles Rams host the San Francisco 49ers at the iconic Melbourne Cricket Ground. The Rams open as 3½-point favorites at -180 on the moneyline, with the 49ers available at +155. The 48½ total reflects a competitive NFC West divisional matchup with both offenses expected to find yards. Bettors should note the neutral-site element; with no true home-field advantage for either team, this line may have more movement than a standard divisional game as kickoff approaches.

What are the favorite types of bets for NFL Week 1?

NFL odds have different categories.

• NFL Spread: One team is the favorite, and that squad can be found with a number and a minus sign next to its points; another is the underdog, and that team will have a plus sign next to its NFL line.
• NFL Moneyline: Also factors in plus and minus signs. A favorite would be minus on a money line; that means Buffalo could be -115, which means one would have to bet $115 to win $100. In the Ravens’ case, they could be +110, which would translate to betting $100 to win $110.
• NFL Totals (over/under): This is an NFL line that is set for the amount of points a bettor believes will be scored; say the total in a game between Teams A&B is 37½ points, the person making the wager determines whether the final score in the game will be more or less than that number of points. Over is more than 37½, and Under is less than 37½.

What key factors influence the setting of NFL Week 1 odds?

NFL odds Week 1 are influenced by what teams did in the previous season and offseason. While the prior campaign doesn’t always dictate success or failure in the next one, it does provide a barometer for how a team has done.

Add in other factors like coaching changes, free-agent signings, trades, and draft picks, and BetUS and all other sportsbooks have a gauge to make a line. Throw in where the game is played, who is home, and who is away, and the thought process can be completed. NFL Week 1 Odds & Betting Lines are a great chance to find the spot to make plays before the season takes its shape.

NFL Odds Week 2 are determined in a big way by what happens in Week 1. Who wins, who loses, what players thrive, and which ones nosedive.

Additionally, home-field advantage influences the decision on where to set the ATS and moneyline. And depending on how many points were scored by teams in Week 1 games, that could impact the totals for Week 2.

What are other types of bets for NFL Week 1?

As mentioned, common types of bets for NFL Week 1 are ATS, Moneyline, and Totals. There are also numerous options in the prop market, and one can tie wagers together on the same game or different ones by making plays.

An aside to NFL Week 1 bets, are futures. They can be found on BetUS and provide opportunities to bet on teams one thinks will win the Super Bowl.

To cash an NFL Super Bowl odds bet, the team you bet on has to win the NFL championship game. The futures markets fluctuate depending on what happens in the offseason and are adjusted week-to-week based on news and game results.

Why Choose BetUS for NFL Betting

Our user-friendly NFL betting platform makes it a breeze to navigate through all the NFL Week 1 odds. Whether you’re looking to place a spread bet, back your favorite team on the moneyline, or wager on the game total, you’ll find all these options and more just a few clicks away. For those seeking even more excitement, explore our wide range of game props that let you bet on specific player performances, team statistics, and game events.

We pride ourselves on offering up-to-the-minute NFL Week 1 odds that reflect the latest NFL news, injury reports, and team developments. This ensures that you always have access to the most current lines when you’re ready to place your bets. Our mobile-optimized site allows you to check odds and make wagers on the go, so you never miss out on a great betting opportunity.