Week 11 features an NFC matchup as the Tampa Bay Buccaneers travel to Detroit to take on the Lions. NFL odds have the Lions as -4½ points home favorites at -4½ (-110), while the Buccaneers are listed as +4½ (-110) as the road underdog.
The total of 49½ points points to one of the highest projected scoring games of the Week 11 schedule. Detroit must win by at least five points to cover the spread, while Tampa Bay can cover by winning outright or losing by four points or fewer. With two explosive offenses expected to put points on the board, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 22, 2026 at 12:00 PM ET
- Spread: Lions -4½ (-110) / Buccaneers +4½ (-110)
- Total: Over 49½ (-110) / Under 49½ (-110)