Week 11 features an interconference matchup as the Arizona Cardinals travel to Kansas City to face the Chiefs. NFL odds have the Chiefs as -11½ points home favorites at -11½ (-110), while the Cardinals are listed as +11½ (-110) as the road underdog.
The total of 44½ points suggests a competitive scoring outlook despite Kansas City entering as a sizable favorite. The Chiefs must win by at least 12 points to cover the spread, while Arizona can cover by winning outright or losing by 11 points or fewer. With Kansas City expected to control the action at home, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 22, 2026 at 12:00 PM ET
- Spread: Chiefs -11½ (-110) / Cardinals +11½ (-110)
- Total: Over 44½ (-110) / Under 44½ (-110)