Week 11 features an NFC matchup as the Minnesota Vikings travel to Mexico City to take on the San Francisco 49ers in an international game. NFL odds have the 49ers as -3½ points favorites at -3½ (-110), while the Vikings are listed as +3½ (-110) as the underdog at the neutral-site venue.
The total of 46½ points points to balanced scoring expectations for this international showdown. San Francisco must win by at least four points to cover the spread, while Minnesota can cover by winning outright or losing by three points or fewer. With both NFC contenders looking to gain an edge in the playoff race on the international stage, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 22, 2026 at 7:20 PM ET
- Spread: 49ers -3½ (-110) / Vikings +3½ (-110)
- Total: Over 46½ (-110) / Under 46½ (-110)