Week 10 features an AFC matchup as the Miami Dolphins travel to Indianapolis to face the Colts. NFL odds have the Colts as -6½ points home favorites at -6½ (-110), while the Dolphins are listed as +6½ (-110) as the road underdog.
The total of 47½ points suggests solid scoring expectations for this conference matchup. Indianapolis must win by at least seven points to cover the spread, while Miami can cover by winning outright or losing by six points or fewer. With the Colts favored by nearly a touchdown and a relatively high total, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 15, 2026 at 12:00 PM ET
- Spread: Colts -6½ (-110) / Dolphins +6½ (-110)
- Total: Over 47½ (-110) / Under 47½ (-110)