Week 10 features an AFC South divisional matchup as the Jacksonville Jaguars travel to Tennessee to face the Titans. NFL odds have the Jaguars as -2½ point road favorites at -2½ (-110), while the Titans are listed as +2½ (-110) as the home underdog.
The total of 45½ points suggests balanced scoring expectations for this divisional matchup. Jacksonville must win by at least three points to cover the spread, while Tennessee can cover by winning outright or losing by two points or fewer. With a narrow spread between two familiar AFC South rivals, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Sunday, November 15, 2026 at 12:00 PM ET
- Spread: Jaguars -2½ (-110) / Titans +2½ (-110)
- Total: Over 45½ (-110) / Under 45½ (-110)