Week 10 features an NFC South divisional matchup as the Carolina Panthers travel to New Orleans to face the Saints. NFL odds have the Saints as -1½ points home favorites at -1½ (-110), while the Panthers are listed as +1½ (-110) as the road underdog.
The total of 43½ points suggests moderate scoring expectations for this divisional matchup. New Orleans must win by at least two points to cover the spread, while Carolina can cover by winning outright or losing by one point. With a narrow spread between two familiar division rivals, this matchup shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline, and total.
- Game: Sunday, November 15, 2026 at 12:00 PM ET
- Spread: Saints -1½ (-110) / Panthers +1½ (-110)
- Total: Over 43½ (-110) / Under 43½ (-110)