MLB odds will be fascinating on Wednesday when Paul Skenes of the Pirates looks to rebound from a dismal opening outing against the Reds. Skenes, whose career ERA is below 2.00, enters with a 2026 mark of 67.50. That is because he was hammered by the Mets in the season opener, lasting only two-thirds of an inning.
Andrew Abbott went six innings against the Red Sox in his 2026 debut, allowing no runs on seven hits. Skenes will have a better outing, no doubt. However, the Reds could have enough pop and pitching to hold their own and should be worth a look on the run line and moneyline in MLB odds.