Must-Watch Games, NFL Week 5 (2025) & Betting Angles
Early Morning Game
Minnesota Vikings vs. Cleveland Browns (Tottenham Hotspur Stadium, London)
Sunday, Oct 5 — 9:30 a.m. ET (NFL Network) International Series
- The Minnesota Vikings and Cleveland Browns are both 2-2 ATS this season.
- On the road or on neutral ground, Minnesota is 1-1 ATS while Cleveland is 0-2 ATS.
- The Vikings are listed as the visitor even though the game is in London. Minnesota is a 3.5-point spread betting favorite.
- Minnesota’s O/U record is 3-1. Cleveland’s is 1-3. The game total is 36.5 points.
Late Sunday Window
Detroit Lions @ Cincinnati Bengals
Sunday, Oct 5 — 4:25 p.m. ET (FOX)
- The Detroit Lions are 3-1 ATS, and the Cincinnati Bengals are 1-3 ATS. The Lions are 9-point spread betting favorites.
- Detroit is 1-1 ATS on the road while Cincinnati is 1-0 ATS at home.
- The Lions are 2-0 ATS as a betting favorite while the Bengals are 0-2 as an underdog.
- Detroit has gone over the total twice and under the total twice this season. Cincinnati’s over-under record is 2-2. This game’s point total is 49.
Sunday Night Football
New England Patriots @ Buffalo Bills
Sunday, Oct 5 — 8:20 p.m. ET (NBC/Peacock)
- Both teams are 2-2 ATS this season. The Bills are 8-point favorites vs the Patriots.
- New England is 1-0 ATS while Buffalo is 1-2 ATS as a betting favorite.
- The Patriots’ over/under record is 2-2, while Buffalo’s is 3-1. The game total is 49 points.
Monday Night Football
Kansas City Chiefs @ Jacksonville Jaguars
Monday, Oct 6 — 8:15 p.m. ET (ESPN)
- The Kansas City Chiefs are 2-2 ATS and the Jacksonville Jaguars are 3-1 ATS. KC is favored by 3 points.
- The Chiefs are 1-1 ATS on the road while the Jags are 2-0 ATS at home.
- Both teams’ O/U record is 2-2 this season. The game total is 45.5.
NFL Week 5 Schedule & How To Watch
Here is the NFL Week 5 schedule for the 2025 season, including dates, times (ET), and how to watch each game.
This week features an international game in London and 4 teams on their bye.
Thursday, October 2nd, 2025
San Francisco 49ers at Los Angeles Rams – 8:15 PM – Prime Video
Sunday, October 5th, 2025
- Minnesota Vikings vs. Cleveland Browns (London, Tottenham) – 9:30 AM – NFL Network
- New York Giants at New Orleans Saints – 1:00 PM – CBS / Paramount+
- Denver Broncos at Philadelphia Eagles – 1:00 PM – CBS / Paramount+
- Houston Texans at Baltimore Ravens – 1:00 PM – CBS / Paramount+
- Dallas Cowboys at New York Jets – 1:00 PM – Fox
- Las Vegas Raiders at Indianapolis Colts – 1:00 PM – Fox
- Miami Dolphins at Carolina Panthers – 1:00 PM – Fox
- Tennessee Titans at Arizona Cardinals – 4:05 PM – CBS / Paramount+
- Tampa Bay Buccaneers at Seattle Seahawks – 4:05 PM – CBS / Paramount+
- Washington Commanders at Los Angeles Chargers – 4:25 PM – Fox
- Detroit Lions at Cincinnati Bengals – 4:25 PM – Fox
- New England Patriots at Buffalo Bills – 8:20 PM – NBC / Peacock
Monday, October 6th, 2025
- Kansas City Chiefs at Jacksonville Jaguars – 8:15 PM – ESPN
Bye week: Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers.
How to Watch NFL Week 5 (2025)
- Thursday Night Football: Prime Video
- London Game (Sunday morning): NFL Network
Sunday Afternoon:
- CBS games stream on Paramount+
- FOX games are available on TV and Fox One (streaming)
- Sunday Night Football: NBC (also on Peacock)
- Monday Night Football: ESPN
- Streaming Bundles: Fubo, YouTube TV, Hulu + Live TV, and DirecTV Stream carry all major networks.
- NFL+: Mobile streaming and out-of-market games.
- NFL RedZone: Live look-ins and highlights during Sunday afternoon games.
Whether you’re betting on spreads, moneylines, game totals, player props, or game props, at BetUS, we’ve got you covered.
Jump into the excitement, place your bets, and enjoy every moment of NFL Week 5.
