This NFC West rivalry gets a historic backdrop to open the 2026 season: the 49ers and Rams meet at Melbourne Cricket Ground in Australia, making it one of the rare NFL international games played outside of the UK or Mexico. NFL odds have Los Angeles as the favorite regardless of venue, sitting at -180 on the moneyline and -3½ on the spread, while San Francisco gets the points at +3½ and is live at +155 on the moneyline.
The total of 48½ is on the higher end for a Week 1 divisional opener, reflecting two offenses the market expects to move the ball in a fast-paced NFC West matchup. A 3½-point spread keeps this firmly in single-score territory — close enough that the 49ers’ moneyline price represents a meaningful number for anyone backing the road upset.
- Game: Thursday, September 10, 2026 at 8:35 PM ET (Melbourne Cricket Ground, Australia)
- Moneyline: Rams -180 / 49ers +155
- Spread: Rams -3½ (-110) / 49ers +3½ (-110)
- Total: 48½ (-110 both sides)