Arizona Cardinals vs Los Angeles Chargers

Sun, Sep 13, 2026 | 4:25P EST
Point Spread Game
Arizona Cardinals
Los Angeles Chargers
Odds Format

Arizona Cardinals at Los Angeles Chargers Odds and Lines

This is the most lopsided matchup on the Week 1 board, with NFL odds positioning the Chargers as the heaviest favorite of any Sunday game. Los Angeles sits at -600 on the moneyline and -10½ on the spread, while Arizona gets the points at +10½ (-110) and comes back at a significant +450 for anyone backing the Cardinals outright.

A -600 moneyline means laying $600 to win $100 on the Chargers, which makes the spread the far more practical handle for bettors on the LA side -10½ at -110 offers the same directional lean at a fraction of the cost. The total of 46 has a slight lean toward the under, with the over priced at -115 and the under sitting at -105, suggesting the market sees a modest edge toward the final score landing below that number despite the Chargers’ offensive firepower.

  • Game: Sunday, September 13, 2026 at 4:25 PM ET
  • Moneyline: Chargers -600 / Cardinals +450
  • Spread: Chargers -10½ (-110) / Cardinals +10½ (-110)
  • Total: 46 (Over -115 / Under -105)

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