This is the most lopsided matchup on the Week 1 board, with NFL odds positioning the Chargers as the heaviest favorite of any Sunday game. Los Angeles sits at -600 on the moneyline and -10½ on the spread, while Arizona gets the points at +10½ (-110) and comes back at a significant +450 for anyone backing the Cardinals outright.
A -600 moneyline means laying $600 to win $100 on the Chargers, which makes the spread the far more practical handle for bettors on the LA side -10½ at -110 offers the same directional lean at a fraction of the cost. The total of 46 has a slight lean toward the under, with the over priced at -115 and the under sitting at -105, suggesting the market sees a modest edge toward the final score landing below that number despite the Chargers’ offensive firepower.
- Game: Sunday, September 13, 2026 at 4:25 PM ET
- Moneyline: Chargers -600 / Cardinals +450
- Spread: Chargers -10½ (-110) / Cardinals +10½ (-110)
- Total: 46 (Over -115 / Under -105)