Must-Watch Games — NFL Week 16 (2025) & Betting Angles
Early Sunday :
Kansas City Chiefs @ Tennessee Titans
Sun., Dec 21 – 1:00 p.m. ET – CBS/Paramount+
- With Patrick Mahomes out after a season‑ending ACL tear, updated NFL odds have tightened considerably.
- Current lines list Kansas City as a modest 3‑point road favorite (-155 ML) with Tennessee at +3, +134, and the total down to roughly 37.5–38.
- Chiefs backers now handicap Gardner Minshew instead of Mahomes, making the shorter spread and moneyline more palatable than the earlier double‑digit chalk; teasing Kansas City up through +3.5 in a six‑point teaser is another way to build cushion.
- Titans bettors can grab the home dog +3 or the +155 moneyline, leaning on a conservative, run‑heavy script to keep this low‑total game within one score.
- Result implications are mostly about pride and evaluation rather than playoff seeding, but a Tennessee win would underscore how dramatically Mahomes’ injury has reshaped the AFC landscape.
Late Sunday Window:
Pittsburgh Steelers @ Detroit Lions
4:25 p.m. – CBS
- Detroit opens -7 on the spread and -325 on the ML.
- Steelers backers can tease Pittsburgh up to +11.5 or target a T.J. Watt sack prop at plus odds.
- Lions supporters chasing value might shift to an alternate line (–9.5) at a bigger payday.
Sunday Night Football:
Cincinnati Bengals @ Miami Dolphins
Sun., Dec 21 – 8:20 p.m. ET – NBC/Peacock
- Updated NFL odds now have Cincinnati as a 4-point road favorite (Bengals -4) with Miami a +180 moneyline underdog and a 47.5-point total.
- Dolphins backers can take the plus money on the ML or grab Miami +4 if they expect a tight primetime finish.
- Bengals believers who trust Joe Burrow on the road might lay the -4, buy down to -3 for a bit more safety, or fold Cincinnati’s side into a two-leg parlay.
- With explosive weapons on both sides, “yardage ladder” props on Ja’Marr Chase and Tyreek Hill should still see plenty of action, and the winner remains firmly in the AFC seeding hunt.
Monday Night Football:
San Francisco 49ers @ Indianapolis Colts
Mon., Dec 22 – 8:15 p.m. ET – ESPN/ABC
- Opening NFL betting lines make San Francisco a 6-point road favorite (-6) with a -271 moneyline and a 46.5-point total.
- 49ers bettors who hate the juice can target an alternate spread (-9.5) at plus money or anchor the ML in a two-team teaser with the under.
- Colts supporters can tease Indy up to +12 or sprinkle the +200 upset, noting their 6-1 ATS mark as a home dog since 2024.
- Prop spotlight: Nick Bosa sack total, Anthony Richardson rushing-yard ladders, and first-TD markets, all expected to drive the Monday-night handle.
Bye Week: None (all 32 teams play).
NFL Week 16 Schedule & How To Watch
Thursday, December 18th, 2025
- Los Angeles Rams at Seattle Seahawks – 8:15 p.m.- Prime Video
Saturday, December 20th, 2025 (*Saturday kickoff times were assigned as part of FOX’s Week 16 double-header)
- Green Bay Packers at Chicago Bears* – 4:30 p.m. – FOX / NFL+
- Philadelphia Eagles at Washington Commanders* – 8:00 p.m. – FOX / NFL+
Sunday, December 21st, 2025 — Early Window
- Kansas City Chiefs at Tennessee Titans – 1:00 p.m. – CBS / Paramount+
- New York Jets at New Orleans Saints – 1:00 p.m. – CBS / Paramount+
- New England Patriots at Baltimore Ravens – 1:00 p.m. – CBS / Paramount+
- Buffalo Bills at Cleveland Browns – 1:00 p.m. – CBS / Paramount+
- Tampa Bay Buccaneers at Carolina Panthers – 1:00 p.m. – FOX
- Minnesota Vikings at New York Giants – 1:00 p.m. – FOX
- Los Angeles Chargers at Dallas Cowboys – 1:00 p.m. – FOX
Sunday — Late Window
- Atlanta Falcons at Arizona Cardinals – 4:05 p.m. – FOX
- Jacksonville Jaguars at Denver Broncos – 4:05 p.m. – FOX
- Pittsburgh Steelers at Detroit Lions – 4:25 p.m. – CBS
- Las Vegas Raiders at Houston Texans – 4:25 p.m. – CBS
Sunday Night Football
- Cincinnati Bengals at Miami Dolphins – 8:20 p.m. – NBC & Peacock
Monday, December 22nd, 2025
- San Francisco 49ers at Indianapolis Colts – 8:15 p.m. – ESPN / ABC simulcast
How to Watch NFL Week 16, 2025
- Prime Video: Exclusive home for Thursday Night Football.
- Saturday Double-Header (FOX): Both games also stream in the Fox Sports app with a pay-TV login; in-market mobile viewing available on NFL+.
Sunday Afternoon:
- CBS games stream locally on Paramount+.
- FOX games stream in the Fox Sports app and, where available, on the upcoming Fox One service.
- Sunday Night Football: Broadcast on NBC and streams nationwide on Peacock.
- Monday Night Football: Simulcast on ESPN and ABC; both streams available in the ESPN app.
- Cord-cutters: YouTube TV, Fubo, Hulu + Live TV, and DirecTV Stream carry CBS, FOX, NBC, ABC, and ESPN, covering every Week 16 telecast.
- NFL+: Offers live local and prime-time games on mobile, plus NFL RedZone for whip-around Sunday coverage.
