NFL odds for Wild Card Weekend on January 10 and 11 spotlight four marquee matchups that open the 2026 playoffs and set the tone for the road to Super Bowl LX.
Rams vs Panthers
The weekend kicks off with the No. 5 Los Angeles Rams visiting the No. 4 Carolina Panthers at Bank of America Stadium, where early NFL odds list the Rams as significant road favorites around -10.5 with a total near 46.5.
Matthew Stafford and a loaded Rams offense face a Panthers team leaning on home-field energy and defense to keep this high-pressure postseason opener close.
Packers vs Bears
In the Saturday primetime slot, the No. 7 Green Bay Packers travel to Soldier Field to face the No. 2 Chicago Bears in a classic NFC North rivalry on the playoff stage.
Books are hanging a tight line with Green Bay -1.5 and a total around 44.5, signaling expectations for a hard-fought, possibly weather-affected battle decided in the fourth quarter.
Bills vs Jaguars
Sunday starts with the No. 6 Buffalo Bills heading to Jacksonville to take on the No. 3 Jaguars in one of the weekend’s most explosive offensive matchups.
Current NFL odds show a short spread and a total in the mid‑40s to low‑50s range, reflecting respect for both Josh Allen and Trevor Lawrence in a potential EverBank Stadium shootout.
49ers vs Eagles
Later Sunday, the No. 6 San Francisco 49ers visit the No. 3 Philadelphia Eagles at Lincoln Financial Field in a star-studded NFC showdown.
Philadelphia is laying about -5.5 with an over/under near 44.5, pricing in the Eagles’ home-field edge and playoff pedigree against a 49ers team capable of flipping the script if its defense controls the trenches.
Chargers vs Patriots
Capping the weekend, the No. 7 Los Angeles Chargers head to Foxborough to face the No. 2 New England Patriots under the lights at Gillette Stadium.
The Patriots sit around -3.5 with a total roughly 46.5, balancing New England’s home playoff aura against a Chargers offense dangerous enough to attract underdog money in a prime-time Wild Card spotlight.
