Detroit opens the season as one of the heaviest favorites on the entire Week 1 board, with NFL odds placing the Lions at -335 on the moneyline and -7 on the spread against a Saints team the market views as a significant step down in class. New Orleans gets the points at +7 (-110) and returns +272 on the moneyline for anyone backing the road upset โ a long-shot price that reflects just how wide the perceived gap between these rosters is heading into 2026.
The total of 50 is tied for the highest mark on the Sunday slate, pointing to an expectation of a fast-paced, high-scoring game at Ford Field rather than a defensive slog. Detroit laying -7 at a clean -110 on both sides suggests the market is fully committed to the Lions covering comfortably, while the elevated total signals confidence in both offenses moving the ball freely even with New Orleans as a heavy underdog.
- Game: Sunday, September 13, 2026 at 1:00 PM ET
- Moneyline: Lions -335 / Saints +272
- Spread: Lions -7 (-110) / Saints +7 (-110)
- Total: 50 (-110 both sides)