Philadelphia heads to Tennessee as a road favorite in Week 2, with NFL odds placing the Eagles at -4½ and the Titans getting the points at +4½, both at standard -110 pricing. Being favored by more than a field goal on the road reflects the market’s view of Philadelphia as the clearly stronger roster despite Tennessee holding home-field advantage.
At 4½ points, the spread sits just past the field-goal threshold, meaning an Eagles win by exactly a field goal would still cover for Philadelphia backers while keeping Tennessee live as a home underdog within one score. The total of 42½ is among the lower marks on the Week 2 slate, pointing to an expectation of a defense-influenced, lower-scoring game rather than a high-scoring affair between these two teams early in the season.
- Game: Sunday, September 20, 2026 at 1:00 PM ET
- Spread: Eagles -4½ (-110) / Titans +4½ (-110)
- Total: 42½ (-110 both sides)