Detroit Lions Week 2 vs Buffalo Bills Week 2

Thu, Sep 17, 2026 | 8:15P EST
Point Spread Game
Detroit Lions Week 2
Buffalo Bills Week 2
Odds Format

Detroit Lions at Buffalo Bills Odds and Lines

Thursday Night Football gets a marquee matchup to open Week 2, with two of the NFC and AFC’s most dangerous offenses meeting in Buffalo. NFL odds have the Bills as a 3-point home favorite at -3 (-110), while Detroit gets the points at +3 (-110) as the road team.
The total of 52½ is among the highest on the entire Week 2 board and reflects exactly what the market expects when these two rosters meet: a fast-paced, high-scoring game where both offenses are expected to move the ball freely from the opening drive. A 3-point spread keeps this firmly in one-score territory, making Detroit a live cover candidate despite playing on the road in what shapes up as one of the more evenly matched games of the young season.

  • Game: Thursday, September 17, 2026 at 8:15 PM ET
  • Spread: Bills -3 (-110) / Lions +3 (-110)
  • Total: 52½ (-110 both sides)

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