NFL Week 2 (2025) — Key Matchups & Betting Angles
Thursday Night Football:
Washington Commanders @ Green Bay Packers – Thursday, Sept 11 — 8:15 p.m. ET (Prime Video)
- Early NFL odds list Green Bay as a 3.5-point favorite, at –180 on the moneyline, with the total set at 48.
- Commanders backers who want an extra cushion can tease Washington up to +7.5 or sprinkle the modest +100 outright price.
- Packers bettors disliking the juice might pivot to an alternate spread (–4.5) at a plus return or anchor Green Bay’s ML in a multi-leg parlay.
- Expect a fresh set of rookie-QB props on Jayden Daniels—passing-yard ladders, anytime-TD markets, and even an INT total—fueling handle in his first Lambeau showcase.
Early Sunday Window:
Buffalo Bills @ New York Jets – Sunday, Sept 14 — 1:00 p.m. ET (CBS/Paramount+)
- Consensus NFL odds open Buffalo –6.5 (–300 ML) with a 46.5 total; the Jets return +250 on the moneyline.
- Bills believers concerned about a late back-door cover can buy a half-point to –8 or drop Buffalo into a six-point teaser with another favorite.
- Jets supporters may grab the generous head start or tie New York +8.5 to the under in a same-game parlay for a juicier payout.
- Look for heavy action on Josh Allen passing-TD props and Sauce Gardner INT props, plus AFC East futures will swing if Gang Green strings two wins in a row.
Late Sunday Window:
Philadelphia Eagles @ Kansas City Chiefs – Sunday, Sept 14 — 4:25 p.m. ET (FOX)
- Early NFL odds (market consensus) list Kansas City as a field-goal favorite (-1) and –105 ML with a 47-point over/under.
- Eagles backers who fear the hook can buy down to +1 or chase the -115 moneyline in a revenge parlay tied to the over.
- Chiefs bettors might attack an alternate spread (–6.5) at plus money, banking on Patrick Mahomes to repay the Super Bowl loss.
- Expect a buffet of anytime-TD props on Travis Kelce and Jalen Hurts, plus live-bet opportunities to middle the total if Arrowhead weather turns.
Sunday Night Football:
Atlanta Falcons @ Minnesota Vikings – Sunday, Sept 14 — 8:20 p.m. ET (NBC/Peacock)
- Prime-time NFL odds open Minnesota -4 with a -195 ML; Atlanta returns +165, and the total sits at 44.5.
- Falcons believers can tease Atlanta up to +11.5 or pair the +175 upset with the over in a same-game parlay.
- Vikings bettors worried about the juice may shift to an alternate spread (–8.5) at a plus tag or anchor the moneyline in a weekend round-robin.
- Rookie-QB duel means robust player-prop menus, Michael Penix Jr. rushing yards, J.J. McCarthy passing TDs, and sack props on both fronts.
- The outcome will ripple through NFC wild-card futures, where both teams hover just outside the top tier.
NFL Week 2 Schedule & How To Watch
*All times Eastern
Thursday, September 11th, 2025
- Washington Commanders at Green Bay Packers – 8:15 PM – Prime Video
Sunday, September 14th, 2025 — 1 p.m. window
- Jacksonville Jaguars at Cincinnati Bengals – 1:00 PM – CBS
- Buffalo Bills at New York Jets – 1:00 PM – CBS
- New England Patriots at Miami Dolphins – 1:00 PM – CBS
- Los Angeles Rams at Tennessee Titans – 1:00 PM – CBS
- Cleveland Browns at Baltimore Ravens – 1:00 PM – CBS
- San Francisco 49ers at New Orleans Saints – 1:00 PM – Fox
- New York Giants at Dallas Cowboys – 1:00 PM – Fox
- Seattle Seahawks at Pittsburgh Steelers – 1:00 PM – Fox
- Chicago Bears at Detroit Lions – 1:00 PM – Fox
- NY Giants at Washington – 1:00 PM – Fox
Sunday, September 14th, 2025 — Late window
- Denver Broncos at Indianapolis Colts – 4:05 PM – CBS
- Carolina Panthers at Arizona Cardinals – 4:05 PM – CBS
- Philadelphia Eagles at Kansas City Chiefs – 4:25 PM – Fox
- Atlanta Falcons at Minnesota Vikings – 8:20 PM – NBC
Monday, September 15th, 2025
- Tampa Bay Buccaneers at Houston Texans – 7:00 PM – ABC
- Los Angeles Chargers at Las Vegas Raiders – 10:00 PM – ESPN
How to Watch NFL Week 2, 2025
- Thursday Night Football: Exclusive on Prime Video (subscription required).
Sunday Afternoon
- CBS games stream locally on Paramount+.
- FOX games stream in the Fox Sports app (pay-TV login) and are expected on the upcoming Fox One service.
- Sunday Night Football: Broadcast on NBC and streams nationwide on Peacock.
- Monday Night Football: Early game on ABC; late game on ESPN (both available in the ESPN app with TV-provider credentials).
- Cord-cutter bundles: YouTube TV, Fubo, Hulu + Live TV and DirecTV Stream carry CBS, FOX, NBC, ABC and ESPN, giving access to every Week 2 telecast.
- NFL+: Live local and prime-time games on mobile plus NFL RedZone for Sunday-afternoon whip-around coverage.
Don’t miss out on the chance to capitalize on your NFL know-how and make Week 2 a winning one!
Head over to BetUS today and explore all the odds and lines for every matchup. Let’s get this football season rolling!
