Seattle opens Week 2 as a double-digit road favorite in this NFC West divisional matchup, with NFL odds placing the Seahawks at -10 and the Cardinals getting the points at +10, both at standard -110 pricing. Being favored by 10 on the road is a strong statement from the market, reflecting a view of Seattle as considerably the stronger roster despite Arizona holding home field in a division game.
A double-digit spread puts this well outside one-score territory — Arizona would need to either win outright or keep the margin within nine to cover, a sizable cushion for backers of the home underdog. The total of 44½ at -110 on both sides lands in the middle range for Week 2, suggesting the market expects Seattle’s offense to contribute to the scoring rather than this being a purely defensive game, even with the lopsided spread implying control by the favorite throughout.
- Game: Sunday, September 20, 2026 at 4:25 PM ET
- Spread: Seahawks -10 (-110) / Cardinals +10 (-110)
- Total: 44½ (-110 both sides)