College Football Week 6 Lines, Totals & Game Props You Can’t Miss
Get set for a loaded Week 6 slate in college football where every spread, moneyline, and total has playoff implications and betting opportunities you won’t want to overlook. Last week lived up to the hype. Week 6 of the college football action doesn’t have as many marquee matchups as last week but we do have a pair of games that feature Top-20 teams. In Tuscaloosa, No. 10 Alabama looks to avoid a letdown against No. 16 Vanderbilt. Then in Tallahassee, No. 18 FSU hosts in-state rival No. 3 Miami. Plus in Gainesville No. 9 Texas goes on the road for their SEC opener against unranked Florida.
Join BetUS & Bet Now to lock in spreads, moneylines, totals, alternate lines, first-half odds, and game props. Don’t forget to check out this week’s NFL betting slate.
College Football Week 6 Notable Matchups
Friday, Oct. 3
- No. 23 BYU vs. West Virginia | 10:30 p.m. | ESPN
Saturday, Oct. 4
- No. 1 Ohio State vs. Minnesota | 7:30 p.m. | NBC/Peacock
- No. 3 Miami (Fla.) at No. 18 Florida State | 7:30 p.m. | ABC
- No. 5 Oklahoma vs. Kent State | 4 p.m. | SEC Network
- No. 6 Texas A&M vs. Mississippi State | 7:30 p.m. | SEC Network
- No. 7 Penn State at UCLA | 3:30 p.m. | CBS
- No. 9 Texas at Florida | 3:30 p.m. |ESPN
- No. 10 Alabama vs. No. 16 Vanderbilt | 3:30 p.m. | ABC
- No. 11 Texas Tech at Houston | 7 p.m. | ESPN
- No. 12 Georgia vs. Kentucky | 12 p.m. | ABC
- No. 14 Iowa State at Cincinnati | 12 p.m. | ESPN2
- No. 20 Michigan vs. Wisconsin | 12 p.m. | FOX
- No. 21 Notre Dame vs. Boise State | 3:30 p.m. | NBC/Peacock
- No. 22 Illinois at Purdue | 12 p.m. | Big Ten Network
- No. 24 Virginia at Louisville | 3:30 p.m. | ESPN2
odds subject to change
How to Bet CFB Week 6 at BetUS
BetUS isn’t just about spreads and moneylines. Sure, you can grab those in seconds. But Week 6 is built for deeper plays. That’s where alternate lines, halves, and props shine.
Want to shorten a favorite from -12.5 to -6.5 for a safer sweat? Hit the alternate line market. Think a shootout starts hot but fizzles late? First-half totals are your friend. Chasing a specific star to hit 100 yards? Player props let you target individual matchups without sweating the scoreboard.
Everything is built mobile-first. Whether you’re on iOS, Android, or your laptop, the BetUS board updates live. That means sharper odds, faster access, and more ways to get action on Week 6.
Betting Markets Explained
Think you know who will win? There are countless ways to bet on the game. Master these markets to find the best value in the college football Week 6 odds.
- The Spread: The Point Spread Is the Great Equalizer in Football Betting. The favorite must win by more than the spread number. The underdog can win outright or lose by less than the number to cover. For example, if Alabama is -14.5, they need to win by 15 or more points. Simple, right?
- The Moneyline Forget the points. The NCAAF Week 6 moneyline is about one thing: picking the winner. The favorite will have minus odds (like -200), meaning you risk more to win less. The underdog has plus odds (+180), offering a bigger payout for the upset. Bet on who you think wins the game straight up.
- Totals (Over/Under) This isn’t about who wins. It’s about how many points are scored. We set a total number for the combined score of both teams. You bet on whether the final score will be Over or Under that number. Check the college football totals if you expect a shootout or a defensive slugfest.
- Props and Alternate Lines This is where you can really find an edge. Don’t like the main line? Check out the alternate college football spreads. Want to bet on a specific player? Bet on college football props for passing yards, rushing touchdowns, and more. Game props let you bet on everything from the first team to score to individual quarter results.
