College Football Week 5 Odds: Lines, Totals & Game Props You Can’t Miss
Get set for a loaded Week 5 slate in college football where every spread, moneyline, and total has playoff implications and betting opportunities you won’t want to overlook. Last week was pure chaos. Six ranked teams went down. Think this week will be any different? With four head-to-head matchups between Top-25 teams, the pressure is on. Playoff dreams are already on the line, and every game feels like an elimination match.
This is your command center for all the College Football Week 5 odds. Stop hunting around; the sharpest NCAAF Week 5 lines are right here. We’re talking about the monster SEC clash between Alabama and Georgia and a top-ten war between Oregon and Penn State. Every key matchup has College Football betting odds ready for action. Beyond the main lines, you can attack the College Football point spreads and totals, and unique game props for every single contest. Find your angle and make your move.
Join BetUS & Bet Now to lock in spreads, moneylines, totals, alternate lines, first-half odds, and game props. Don’t forget to check out this week’s NFL betting slate.
Opening Lines For Key Week 5 Matchups
The board is packed with high-stakes games. Here’s a look at the opening College Football moneyline odds and spreads for the weekend’s biggest contests.
Saturday, September 27
- No. 21 USC (-6.5) at No. 23 Illinois (Noon ET, Fox)
- No. 1 Ohio State (-8.5) at Washington (3:30 p.m. ET, CBS)
- No. 4 LSU at No. 13 Ole Miss (-2.5) (3:30 p.m. ET, ABC)
- Auburn at No. 9 Texas A&M (-6) (3:30 p.m. ET, ESPN)
- No. 6 Oregon at No. 3 Penn State (-3.5) (7:30 p.m. ET, NBC)
- No. 17 Alabama at No. 5 Georgia (-3) (7:30 p.m. ET, ABC)
odds subject to change
Lock In Your Week 5 College Football Bets
The lines are live and the board is set. Six of these teams are viewed as legitimate playoff contenders, and this weekend will separate the real threats from the pretenders. What are the odds for College Football Week 5? They’re all right here.
Now, the choice is yours. Explore the full menu of College Football Week 5 odds, check out the player props for every star player, and build your perfect betting slip. Don’t wait for these lines to move. Bet on College Football now and get in on the action.
How to Bet CFB Week 5 at BetUS
BetUS isn’t just about spreads and moneylines. Sure, you can grab those in seconds. But Week 4 is built for deeper plays. That’s where alternate lines, halves, and props shine.
Want to shorten a favorite from -12.5 to -6.5 for a safer sweat? Hit the alternate line market. Think a shootout starts hot but fizzles late? First-half totals are your friend. Chasing a specific star to hit 100 yards? Player props let you target individual matchups without sweating the scoreboard.
Everything is built mobile-first. Whether you’re on iOS, Android, or your laptop, the BetUS board updates live. That means sharper odds, faster access, and more ways to get action on Week 4.
Betting Markets Explained
Think you know who will win? There are countless ways to bet on the game. Master these markets to find the best value in the college football Week 4 odds.
- The Spread: The Point Spread Is the Great Equalizer in Football Betting. The favorite must win by more than the spread number. The underdog can win outright or lose by less than the number to cover. For example, if Alabama is -14.5, they need to win by 15 or more points. Simple, right?
- The Moneyline Forget the points. The NCAAF Week 4 moneyline is about one thing: picking the winner. The favorite will have minus odds (like -200), meaning you risk more to win less. The underdog has plus odds (+180), offering a bigger payout for the upset. Bet on who you think wins the game straight up.
- Totals (Over/Under) This isn’t about who wins. It’s about how many points are scored. We set a total number for the combined score of both teams. You bet on whether the final score will be Over or Under that number. Check the college football totals if you expect a shootout or a defensive slugfest.
- Props and Alternate Lines This is where you can really find an edge. Don’t like the main line? Check out the alternate college football spreads. Want to bet on a specific player? Bet on college football props for passing yards, rushing touchdowns, and more. Game props let you bet on everything from the first team to score to individual quarter results.
