March Madness is the ultimate test of skill, luck, and heart. With 68 teams battling for the 2026 NCAA Men’s Basketball Championship, a single buzzer-beater, Cinderella run, or shocking upset can bust brackets and shake up the College Basketball odds instantly.
Whether backing a powerhouse program or rolling the dice on a long shot, BetUS has your ticket to the Big Dance with the best odds and biggest markets on March Madness.
Top Betting Markets for March Madness
- March Madness Championship Odds: Bet on which team cuts down the nets as NCAA Tournament champion, from blue-bloods like Michigan, Arizona, and Duke to Big 12 and SEC contenders making a run at the Big Dance.
- March Madness Point Spreads: Wager on the margin of victory in individual March Madness games, backing favorites to cover big numbers or Cinderella underdogs to keep it close and cash their ticket.
- March Madness Totals (Over/Under): Predict whether the combined score in a March Madness matchup will go over or under the BetUS line, using tempo, offensive efficiency, and defensive strength to target high‑flying shootouts or grind-it-out unders.
- March Madness Team Props: Focus on team‑based outcomes during the tournament, such as total points, 3‑pointers made, largest lead, or race‑to‑point milestones that let you zero in on how a squad performs rather than just who wins.
- March Madness Player Props: Wager on individual star performances, including points, rebounds, and assists for key players on programs like Michigan, Duke, Houston, or Florida, and ride breakout tournament runs or favorable matchups for extra value.
Get ahead of the action at BetUS Sportsbook and lock in your bets for March Madness today, from long-range futures to game‑by‑game markets all tournament long.
Tempting Odds in NCAA Championship Futures
The NCAA men’s basketball championship futures area on BetUS offers some of the most enticing futures in the entire industry. March Madness odds see Michigan as co-favorites at +450 with Arizona.
Where else can one find such juicy wagering opportunities on powerful teams in any other sport?
The Wildcats are in the midst of a four-game run against ranked teams. They suffered their first loss of the season at Kansas.
That was a four-point defeat. On Valentine’s Day, they played at home against Texas Tech in another Big 12 contest and lost again. Do not be surprised to see their current odds to win March Madness head North.
Some believe a loss is good to relieve the pressure of being undefeated heading into the Big Dance. Two losses could suggest vulnerability.
Michigan upped its mark to 24-1 with a Valentine’s Day victory over UCLA. The Wolverines are a force. Their lone loss was by three points to Wisconsin, another strong Big Ten team. Michigan averages better than 90 points per game and has a balanced attack.
Three of the next four games are against ranked teams, conference clashes at Purdue and Minnesota sandwiched around contests with Duke and Minnesota. The Duke game will be the Edward Jones Capital showcase on a neutral floor at Capital One Arena.
Big 12 Teams Fit Championship Mode
College basketball futures lines have some Big 12 teams that merit serious consideration. Houston is listed at +750.
The risk with these Cougars is that they have never won an NCAA championship. They have had all sorts of talent and opportunities, but never gotten the job done.
NCAAB picks and parlays could be used to set oneself up for Big 12 teams to meet somehow in the national championship game.
Kansas is at +2400 and already has defeated Arizona. If Darryn Peterson can find a way to stay on the court, the Jayhawks could have a big chance to go deep in the tournament.
Another school in this conference to consider is BYU. The Cougars are listed at +6000, and they boast a talented roster.
Another Big 12 school to remember is Iowa State, which is +1200 based on a 22-3 mark. The Cyclones walloped Kansas on Saturday, gaining revenge for a 21-point loss in Lawrence earlier this season.
