Week 11 kicks off with an AFC South divisional matchup as the Indianapolis Colts travel to Houston to face the Texans on Thursday Night Football. NFL odds have the Texans as -5½ points home favorites at -5½ (-110), while the Colts are listed as +5½ (-110) as the road underdog.
The total of 45½ points points to moderate scoring expectations for this divisional showdown. Houston must win by at least six points to cover the spread, while Indianapolis can cover by winning outright or losing by five points or fewer. With an important AFC South matchup opening the Week 11 slate, this game shapes up as an intriguing betting option for NFL bettors looking at the spread, moneyline and total.
- Game: Thursday, November 19, 2026 at 7:15 PM ET
- Spread: Texans -5½ (-110) / Colts +5½ (-110)
- Total: Over 45½ (-110) / Under 45½ (-110)